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Framework for understanding the neurophysiologic mechanisms of dyspnea during exercise in patients with COPD journals.lww.com/co-pulmonaryme…

Several interesting points in this figure: 1) ex-smokers with COPD are less likely to have cough or phlegm than current smokers; 2) more extensive mucus plugging is associated with lower percentage of patients without these symptoms #COPDGene journal.chestnet.org/article/S0012-… CHEST

Procalcitonin-guided antibiotic therapy for patients with exacerbations of COPD significantly reduced the rate of antibiotic prescriptions without negatively affecting treatment success rate or other outcomes. doi.org/10.1016/j.cmi.… Clinical Microbiology and Infection

Low birth weight is associated with increased risk of COPD, but also has interactions with maternal smoking, older age and passive smoking. Low birth weight and smoking during pregnancy have a joint effect. bmjopenrespres.bmj.com/content/11/1/e…

Our latest study is now online in JAMA Network Open, reporting on the limited estimative performance of exacerbation (ECOPD) history categories by GOLD. Novel cutoffs based on a history of 1 or more moderate ECOPD, 1 or more severe ECOPD, or both within 12 months are suggested.

Patient-reported outcome measures (PROMs) are poorly related to clinical measures in severe asthma, but PROMs are prone to changes in usual care, with exacerbations playing a key role. doi.org/10.1186/s12955… #asthma

Impact of home non-invasive ventilation in chronic hypercapnic respiratory failure due to COPD. Initiation of home noninvasive ventilation in hypercapnic chronic obstructive pulmonary disease: when, where, and how? - PubMed (nih.gov)

Epidemiological study reports no association between inhaled corticosteroid (ICS) and risk of major adverse cardiovascular events (except heart failure) in COPD. Thus, potential ICS-related cardioprotection remains to be established. ThoraxBMJ Inhaled corticosteroids and major

Proposal for the management of cardiovascular risk factors and disease in patients with COPD doi.org/10.1080/147790…

PDE3 and PDE4 contribute to inflammation and airway smooth muscle contraction, that is evident in conditions such as COPD. Dual inhibition of these enzymes may provide clinical benefit to a broad range of patients with COPD and represents a promising new treatment strategy.

The worldwide prevalence of shortness of breath in adults is approx. 14%, with a wide variation across sites. Furthermore, it is strongly associated with spirometric obstruction and restriction. #BOLD sciencedirect.com/science/articl…

New meta-analysis shows a significant 20% reduction in all-cause mortality with ICS-containing therapies versus non-ICS containing inhaler therapies in COPD. Future research should identify patient subgroups most likely to benefit while minimizing adverse effects.

Hard to comprehend and even harder to accept: a 46.3%, or 35 year (!), loss of life expectancy in the Gaza Strip during the period October, 2023, to September, 2024. Touched by this The Lancet paper. doi.org/10.1016/S0140-…

Theoretical framework illustrating the potential impact of body composition on COPD exacerbation risk; from our latest editorial in Respirology Felipe V. C. Machado doi.org/10.1111/resp.7…

Targeting T2 inflammation or epithelial-derived alarmins represents a step forward in precision medicine for the treatment of a subset of COPD... sciencedirect.com/science/articl…

Almost 31% of persons hospitalized with severe RSV infection has underlying COPD and in-hospital mortality in this group may be as high as 18%. Preventive vaccins are available but need to be implemented. springernature.com/gp/open-resear…

Pulmonary rehabilitation is an evidence-based, personalized, comprehensive intervention that improves physical and psychological function and reduces healthcare consumption in people with chronic respiratory conditions #PRweek2025 #COPD

Newly proposed diagnostic schema for COPD using major and minor criteria classifies individuals as having this disease beyond airflow limitation and identifies individuals at increased risk for poor outcomes. doi:10.1001/jama.2025.7358 JAMA

Airway mucus plugs were previously associated with increased risk of exacerbations and mortality in COPD. Now, persistent and newly formed mucus plugs are associated with a faster decrease in lung function (FEV1) in this disease. NEJM nejm.org/doi/abs/10.105…