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Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma dlvr.it/SS7TqG

Very happy to share our latest manuscript Cell with you: authors.elsevier.com/c/1fVaEL7PXipIV TL;DR: Glioblastomas are incurable brain tumors colonizing the entire brain. We overlay molecular and functional data to uncover a hijacking of neuronal mechanisms driving invasion.

We'd love to hear back from the community about GBMdeconvoluteR, our tool to infer relative proportions of cancer & TME cells from bulk GBM RNAseq data biorxiv.org/content/10.110… Made possible thanks to funding from UK Research and Innovation Yorkshire's Brain Tumour Charity OSCAR's PBTC IBIN BNS Neuropathology

🎉 Congrats to The Jackson Laboratory Summer Student alumni Emma Wade (left) & Gordon Ye (right) for being selected as 2023-24 Churchill Scholars! This competitive scholarship covers one year of master’s study at Churchill College, a stipend and travel costs. Read more: bit.ly/3XzMLI6

Congratulations to former summer student Gordon Ye!

We just published in Neuro-Oncology 🥳 GBMdeconvoluteR quantifies immune & neoplastic cells in bulk RNAseq of IDHwt GBM:tinyurl.com/2bpueaas. More research facilitated by Leeds Neuropathology Research Tissue Bank funded by Yorkshire's Brain Tumour Charity and OSCAR's PBTC.

We think we've found something v.interesting 🧐:IDHwt GBMs can be stratified by treatment response which might inform targeted therapies. Read our study here: tinyurl.com/3ybvwutd Funded by UK Research and Innovation Brain Research UK MRC DiMeN Diversity Leeds Hospitals Charity OSCAR's PBTC Yorkshire's Brain Tumour Charity

Online Now: Transcriptome analysis reveals tumor microenvironment changes in glioblastoma dlvr.it/Skh20l

It's Ph.D. application season! Ready for the next step in your scientific career? #PhDchat Learn more & apply for JAX's exceptional Ph.D. program in mammalian genetics, neuroscience, or biomedical sciences: jax.org/phd

We are thrilled to have published our recent findings regarding the way that GBM tumours adapt to, and survive, treatment in Genome Biology. This brief thread highlights what we found: 1/8