Wonderful to have our paper on a MECOM-regulated gene network in human hematopoietic stem cell maintenance and leukemia published in Nature Immunology! Terrific work from our group led by Richard Voit, Tao Liming, and Fulong Yu: nature.com/articles/s4159…

Thanks James Zou for the support! I work on integrating #GWAS and #FunctionalGenomics. I also develop general #MachineLearning algorithms, for adaptive inference, multiple testing, etc. DM me if you are interested or have faculty job opportunities😉

Why do Latino children have the highest risk for childhood leukemia in the US? We identify one cause for this in a paper out in Cell Genomics today, led by Adam de Smith, Lara Wahlster, Soyoung Elizabeth Jeon, Fulong Yu, Charleston Chiang, & colleagues: cell.com/cell-genomics/…

Published today, our reasons for optimism that success rates in drug discovery can be improved by picking the right targets using human genetics: nature.com/articles/s4158… I break the key findings down panel by panel in this thread: x.com/cureffi/status…

CRISPR-GPT: An LLM Agent for Automated Design of Gene-Editing Experiments Use Agent "to facilitate the process of selecting CRISPR systems, designing guide RNAs, recommending cellular delivery methods, drafting protocols, and designing validation experiments to confirm editing

Finally, Taylor Swift explains her own theorem.

20 years ago I was finishing my first year at Harvard Medical School... Never did I imagine I would be here today. Grateful to all the incredible lab members past and present, amazing mentors, remarkable colleagues, and others who have made this possible! 🙏 for all those who wrote letters!

How has the AI boom impacted algorithmic biology? Voices piece Cell Systems from Mona Singh Cenk Sahinalp & Team Jianyang (Michael) Zeng Wei Vivian Li Carl Kingsford Qiangfeng Zhang Teresa przytycka Josh Welch Bonnie Berger Lab and myself

I am tremendously honored to join this amazing cohort of HHMI Investigators! I am incredibly fortunate to have worked with incredible people in our laboratory and excited for all that we will be able to do in the coming years!

Should mutations called from the read ends be excluded from downstream analyses? It certainly depends! The excellent analysis offers new insights and hopefully clears up confusion within the lineage tracing community using mtDNA.

An important thread on our latest preprint 👇👇. Also highlights the incredible resilience and dedication of a brilliant scientist and an exceptional human being. So proud of you, Chen Weng! 🙏 also to my friend and collaborator, Jonathan Weissman's Lab!

Nature research paper: Deciphering the impact of genomic variation on function go.nature.com/4e6lmFk

Wonderful to see this work from Jorge Diego Martin-Rufino and #AlexisCaulier from our lab out in #bioRxiv! Please check out our development and application of Perturb-multiome to enable systematic mapping of genetic variation impacting hematopoiesis!

Excited to share that scPRS is now out Nature Biotechnology! We developed a new single-cell-resolved #PRS using deep learning. nature.com/articles/s4158…