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Simple models of non-random mating and environmental transmission bias standard human genetics statistical methods biorxiv.org/cgi/content/sh… #biorxiv_genetic

Revealing the range of maximum likelihood estimates in the admixture model. biorxiv.org/cgi/content/sh… #biorxiv_genetic

REGENIE v4.0 is live!🎉 You can now analyze time-to-event phenotypes, leveraging power gains with case-control phenotypes where time-to-event information is available. github.com/rgcgithub/rege…

A consensus variant-to-function score to functionally prioritize variants for disease biorxiv.org/cgi/content/sh… #biorxiv_genetic

GLEANR: Sparse matrix factorization of GWAS summary statistics robust to sample sharing improves detection and interpretation of factors with diverse genetic architectures biorxiv.org/content/10.110…

Kicking off the new year, our paper by Leo Speidel et al. is out describing what to me is a breakthrough in ancient genomics. By using genealogies to study ancestry we can get much more resolution to study finer-scale history. We call this method Twigstats.

Happy New Year! Our Twigstats paper is now out! nature.com/articles/s4158…

Amazing work, huge congrats, Hrushi

A General Framework for Branch Length Estimation in Ancestral Recombination Graphs biorxiv.org/content/10.110… #biorxiv_evobio

VERY excited to announce a pre-print that represents the culmination of several years of work*: “On ARGs, pedigrees, and genetic relatedness matrices” doi.org/10.1101/2025.0… Led by Brieuc Lehmann with contributions from Hanbin Lee Luke Anderson-Trocmé Jerome Kelleher Peter Ralph

I'm very happy that our paper on admixture in deep human evolution is out now in Nature Genetics! nature.com/articles/s4158… Thanks very much to my PhD supervisors Aylwyn Scally and Richard Durbin for their support throughout

Mutation-selection-drift balance models of complex diseases biorxiv.org/content/10.110… #biorxiv_genetic

The preprint has been accepted at Genome Biology. We studied how admixed GWAS works under the STRUCTURE model. Simple tweaks to improve power and important methodological insights. (1/n) medrxiv.org/content/10.110…

Postdoc position in my group in Tokyo! Please get in touch if you are interested. And happy to discuss projects - ranging from developing new methods to analysis of new genomes that we are now sequencing in the lab. riken.jp/en/careers/res… Lab page: speidellab.github.io

Grok 4 is the first time, in my experience, that an AI has been able to solve difficult, real-world engineering questions where the answers cannot be found anywhere on the Internet or in books. And it will get much better.

The HLA region is key to human health, but is often excluded in large-scale GWAS. Informing future studies on its influence, AJHG' latest article reports HLA haplotype-based associations across thousands of diseases: bit.ly/4lrJiXT #ASHG Jonathan Pritchard

New preprint! We unveil the profound connection between the Ancestral Recombination Graph and Linear Mixed Models. Guess what? Random effects are merely a consequence of mutations running on a fixed genealogy. biorxiv.org/content/10.110…

Happy to share that our work from the Nicholas Mancuso lab is out in Nature Genetics! We developed SuShiE, a multiancestry fine-mapping method for molecular traits. doi.org/10.1038/s41588…