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🚨New preprint posted🚨 Protein turnover is regulated by learning and disease processes. We developed a method (DELTA) to quantify the rate of protein turnover across the whole brain, with single synapse resolution. biorxiv.org/content/10.110… 🧵 1/7

Check out our new bioRxiv preprint that challenges the recent in vivo optical clearing paper with tartrazine dye in Science. To be clear, they only demonstrated optical clearing of *dead cells*. Tartrazine cannot make live tissues transparent doi.org/10.1101/2024.0…

The first wiring diagram of the whole brain of a fruit fly, containing around 140,000 neurons and over 50 million connections, is presented in a paper in nature. go.nature.com/3BChkqa

…. and only around 14 hours until the famous call from Stockholm. Here’s the phone I’ll use. If you expect the call, please stay alert @ around 9.30-10 CEST tomorrow!

Sydney Brenner established C. elegans as a model organism starting in the 1960s, which led to the first connectome in 1986. In Sept 2007, we invited Sydney to deliver the inaugural lecture for our new Harvard University Massachusetts Institute of Technology (MIT) class on connectomics, and shockingly he accepted!

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

Wow. Hopfield model and Boltzmann machine.

I am delighted that Princeton University‘s own John Hopfield was co-awarded this Nobel. In addition to being a foundational figure in neural networks, John has been a great colleague & friend to so many in our neuroscience community. He’s been a source of ideas, mentoring, and friendship.

Reconstructing a whole brain means you can map sensation to cognition #FlyWire

I'm hiring! Come for the models 🖥️ but stay for the science 🧬🧫⚗️🧪 :) Join AI at Meta to advance our understanding of LLM capabilities in science. Strong preference for those with deep experience in bio, chem, LLMs, and a deep love of good evals :) metacareers.com/jobs/561660669…

We're hiring!! → talmolab.org/join/

Junior software engineer position now open to applications! recruiting2.ultipro.com/SAL1013SIBS/Jo… All positions still available: talmolab.org/join/#open-pos…

Great news! Grateful that we recieved 4.4 million SEK from Vetenskapsrådet to study the sequence dependence of transcription factor - DNA binding: vr.se/english/applyi… There is also 11 days left to apply to this Postdoc position in my lab. Apply: scilifelab.se/career/postdoc…

Want to be part of the NeuroAI community Cold Spring Harbor Laboratory? Applications are open for outstanding graduate students in Artificial Intelligence to spend the summer at CSHL as NeuroAI Interns. Deadline: Dec 10th, 2024. Please spread the word. Apply here - schooljobs.com/careers/cshl/j…

I'm excited to release what I've been cooking up the past few months at Arc Institute BINSEQ is a family of binary file formats for sequencing data built with paired records and parallel processing in mind with big performance gains (2x-40x) over gzip-fastq with similar storage

Antibodies don't work. NLRP3 is by far the most studied inflammasome — yet <30% of commercial antibodies were specific. Only 4 of 14 tested antibodies detected NLRP3 specifically. Antibodies must be validated before use. Full report by YCharOS zenodo.org/records/116239…

The premier conference on Machine Learning for Computational Biology is Sep 9-10 at the NY Genome Center in NYC! Submission deadline is June 1 for 2-page abstracts and 8-page papers (eligible for proceedings track). Registration is now open! (Link below) Please retweet!

The scientific literature is at risk of becoming flooded with papers that make misleading health claims. nature.com/articles/d4158…

The war on science in the US is already affecting private sector research like AlphaFold. Bears repeating but the private sector builds on top of things created by academic research for the public good. This hurts everyone.

Postdoc positions available in my lab Karolinska Institutet - exciting science and fantastic environment. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. shorturl.at/sj2YE