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Honestly, if a few years ago you told me I'd be excited about circRNAs, I would have told you you were crazy. Though initially discarded as by-products of splicing, it's now clear that circRNAs have a substantial role in cancer. Check out our latest Review to learn more!🤓

My latest research highlight focuses on work from Julien Marie's group (Cancer Research Centre of Lyon) where they identified a T cell subset (Th17 cells) capable of initiating intestinal cancer. Check it ooouuuttt 👇

I can confirm that she's worth chatting with!! 😎

How is it September already?! Check out our latest issue now. If it's not already clear, our cover this month is inspired by our review on #circRNAs in cancer. Happy reading! 🤓

Me updating my email signature to "Senior Editor":

📢 Hot off the press! CAFs are major regulators of the immune tumor microenvironment. In our new review we dissect a fascinating aspect of this regulation: CAF-induced physical constraints controlling T cell state and localization in solid tumours nature.com/articles/s4156…

Rescue and recovery responders of the WTC disaster suffer 9/11-related cancers. Zeig-Owens&Prezant FDNY Albert Einstein College of Medicine - Official summarize cancer incidence and outcome studies in this population, highligting the need for a dedicated health programme response. go.nature.com/3XnAhEh

In our latest Review, Ruth Shouval, Arpinati & Carradori (Weizmann Institute) summarize how CAF-induced ECM production controls T cell state and localization in solid tumours, ultimately impacting tumour progression, metastasis & therapy response. go.nature.com/3XKu9HK

Oh em gee. I thought I'd mixed up dates when I wrote this tweet.. but it really is October tomorrow 🐈‍⬛😱 In any case, there are lots of goodies in our latest issue, so happy reading! (And Happy October! 🥲)

CRISPR screens are invaluable tools for cancer research, yet standard cell cultures fail to mimic the metabolic complexity of tissues. Here, Zuber & Palm connect these key ideas to highlight how modelling tumour-associated metabolism could enhance screen utility & cancer biology.

It's always fun working on Reviews with topics that align with my studies🤓 This one examines emerging and diverse roles for compressive stresses in solid tumours and the potential for targeting it. Wish I'd been able to read it during my PhD!!

Here is another review that I'm suuuper excited to see online! This one summarizes the role of local + systemic immunity in metabolic disorders & the associated cancers. I'm particularly interested in how the ⬆️ing use of metabolism altering drugs (Ozempic 👀) will impact this.

Happy Thanksgiving to all my fellow Canadians! 🍁🧡

Check out our latest Tools of the Trade from Siyu He on Starfysh! It uses deep learning, archetypal analysis of H&E and known cell markers to identify tissue-specific cell states, without single-cell reference data. Super interesting stuff!! 🤓

Though the microbiome’s role in cancer is still under debate, I lead this collection to showcase the insights that current research has provided us about its functional impact on cancer. Check it out!

The The Cancer Dependency Map is an invaluable, publicly available data repository & research platform for systemically identifying cancer vulnerabilities. Now, Bill Hahn & team review the impact, current uses + limitations of DepMap & the efforts to improve + expand its use. 🤓

Things are ✨changing✨, so I made a bluesky account. Hope to see ya there!! gabriellebrewer.bsky.social

#natureconference🚨 Together Joao Monteiro, Pep Pàmies, Francesca Cesari and I are organizing a Nature Conferences on Gene & Cell Therapies. Come join us in Wenzhou in April! 👇more details: conferences.nature.com/event/GeneCell… nature Nature Biomedical Engineering Nature Medicine Nature Reviews Cancer

There really is nothing like a Keystone meeting 👌 Hope to see you there!

So excited to share this with you all!😃Rama Khokha and I revisit a core assumption in cancer biology: is tumour heterogeneity a reflection of disorganization? Our thoughts on how self-organization shapes tumour tissues, and why that matters for oncology: nature.com/articles/s4156…