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Dr Yamada @ClintonHealth University of Michigan Gates Foundation Frazier Healthcare Partners Takeda GSK delivered his presidential choice lecture AASLD on how to improve the health of many millions in need around the world with passion, grace and vision #LiverMtg19

Wrapping up #LiverMg19 with new promises: Late-breaking abstract session begins with interim analysis of phase 2a LIK066X2204, licogliflozin 30 vs 150mg in bx-proven or diabetic #NAFLD. ALT decrease is only primary endpoint, met with higher dose after 12 AASLD

Same place, (almost) same time: Liver Meeting 2020 back to Boston #LiverMtg19 AASLD

Licogliflozin improved A1c and liver PDFF in #NAFLD with both 30 and 150mg dosing at 12 weeks with mixed and mild effect of fibrosis markers as reported by Dr Stephen Harrison AASLD #LiverMtg19

LIFT-HDV phase 2a study report on using lonafarnib, ritonavir and PEF-IFN lambda for 24 weeks in delta hepatitis by Dr Christopher Koh. Primary endpoint >2log #HDV RNA decline from 4.74 baseline average was met with 3.18 log drop at 24wks NIH NIDDK AASLD #LiverMtg19

Saroglitazar effects in 106 noncirrhotic #NAFLD cases, reported by Dr Gawrieh @IUHepatology. Primary endpoint ALT drop at 16wks met at all doses with 44% peak reduction. HOMA-IR (but not A1c), TG, HDL, PDFF and ELF impact only significant at 4mg. AASLD #LiverMtg19

#FMT affects brain inflammation and glia activation: Jasmohan Bajaj transplanted stools of HE patients into germ-free mice and found higher frontal cortex markers IBA-1, IL1beta and MCP-1 if FMT done before abx Rx. Stool supernatant had no effect. AASLD #LiverMtg19

Leon Schiff state-of-the-art lecture by Dr Josip Llovet Mount Sinai Health System and BCLC GROUP on molecular pathogenesis and management of #HCC AASLD #LiverMtg19

Interim regenerate phase 3 (OCA) results are published. No efficacy on NASH endpoint. A signal on fibrosis with only 25mg, but can’t ignore 50% who get pruritus and 9% drop out. Really need to know predictors of response #Nash Ian Rowe Phil Newsome Richard Parker

Retirement dinner honoring Raj Goyal to mark an era of renowned clinical research and outstanding patient care at VA Boston HC as we all continue to look for guidance and wisdom from this humble giant and pioneer of gastrointestinal physiology. American Gastroenterological Association (AGA) Gastroenterology

Holly Green - Weather Presenter I guess a truly international palindrome will never happen again as long as there are some *crazy* languages such as Hungarian in which the date begins with the year (2020.02.02). Fortuitously, however, the Hungarian version happens to be just another palindrome! Holly Green - Weather Presenter

Glad to share our recent OA review on #NAFLD and portal hypertension explorationpub.com/Journals/em/Ar… describing EUS-guided measurement of the portal pressure gradient and set to change the perception that PPG is not a major player until it is high enough to call "clinically significant"

Thank you AASLD for a terrific #TLMdX that allowed so many friends, colleagues, and even #NobelPrize2020 laureates to bring the best and latest in our field straight to my living room during the past 4 days! AASLD President Jorge Bezerra Michigan Hepatology Ray Chung

Just published a brief letter in Journal of Hepatology arguing to keep #NAFLD as an acronym over #MAFLD as a newly proposed term. The new conceptual framework is great, but the familiar abbreviation could remain if 'nonalcoholic' becomes 'nutrition-associated'! authors.elsevier.com/a/1cTtvcOnAGcdm

Glad to see our provocative piece written with the great jaumebosch on subclinical #portal hypertension in Journal of Hepatology, promoting the paradigm that mechanosignaling pathways in #NAFLD link early increase in #sinusoidal pressure to #fibrosis authors.elsevier.com/a/1e6SOcOnAJDRa

Glad to share our latest work published in Journal of Hepatology on #mechanotransduction and #NAFLD. The following link will allow anyone to have free access for the next few weeks: authors.elsevier.com/a/1fqhXcOnAN3y…