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This was a fun one — new Endpoints Slack interview with Patrick Hsu: endpts.com/endpoints-slac…

1/ 🧵 THREAD: Here’s how we solved a 30-year mystery about an HIV drug. 💊 A drug used for over two decades ⚠️ Pulled from the market for cardiac risk 🤯 And no one knew why — until now We found the missing mechanism using our single-cell mosaic dataset, Tahoe-100M. Let’s talk

So excited to share this preprint, the first with the experiments also done in our team at Institut Curie! From generating tRNA expression atlas to discovery of a tRNA-specific transcription factor, via translational control and breast cancer metastasis. Check it out!

We're hiring! Our group Arc Institute and Stanford University has postdoc openings in 1) discovering and developing next-generation therapeutic delivery vehicles, and 2) tracking cellular dynamics. Email me if you're interested! hornslab.org

“I think you’d be shocked how often people are willing to chat and help you out.” Breaking into AI for Science can feel intimidating. That’s why I found Alishba Imran 's story so inspiring: an undergrad at UC Berkeley, she carved her own path through study groups, shadowing

Join us today for the BMG Seminar Speaker Dr. Hani Goodarzi! Hani Goodarzi Hosted by Dr. Saeid Parast Saeid Parast Shilatifard Lab #epigenetics #oncology Northwestern Feinberg School of Medicine Northwestern Medicine Arc Institute UCSF Biochemistry UCSF Helen Diller Family Comprehensive Cancer Ctr

My conversation with Jony Ive yesterday at Stripe sessions.

We're getting ready to kick-off the Hackathon Weekend 🚀 #TahoeDeepDive

Sad to have missed this! It’s a Tahoe weekend! Go Tahoe Therapeutics (Formerly Vevo)

Shoot for the moon. Build openly. That's the spirit of Tahoe Therapeutics (Formerly Vevo) #tahoedeepdive. 40 people from across the world, self-organized into teams to play with Tahoe-100M and build open models of how biology interacts with chemistry.

#TahoeDeepDive 💙

Our GPUs are humming, supporting this awesome group ❤️

Delighted to publicly launch @Stylus_Medicine today to program the human body into a cell therapy factory to fight cancer. It's a privilege to work with Emile and Jason as CEO/CSO of Stylus and our earliest believers Josh Resnick/Ness Bermingham from RA Capital + Khosla Ventures

Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new Arc Institute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement

Read the full preprint below 👇 If you're interested in the interface of bioengineering, DNA and virtual cell foundation models, and agentic reasoning, shoot me a note. We're hiring postdocs and ML researchers and starting some crazy new projects biorxiv.org/content/10.110…

Very grateful to be a part of this amazing team! It was truly thrilling to see bridge RNAs go from discovery in prokaryotes to application in human cells in such a short period of time! Can't wait to see more people use this remarkably elegant DNA rearrangement system.

"Does it work in human cells?" is a question I've gotten a lot this past year. Excited to share our latest work on bridge recombinases! It's been a lot of fun to lead this team effort. If you are excited to hear more, join for my thesis defense tomorrow at 3pm PT. Links below:

The Arc Institute keeps crushing it. Big step up in specificity and insertion efficiency for human genome engineering with bridge RNAs.

"In new Arc Institute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement."

Really excited to see this published! From observations we made in our lab… to a blood test that works in real life scenarios… all thanks to the many scientists, ML researchers and engineers at exai bio who have worked on bringing this to the clinic. Kudos Babak and the team!