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N>17,000 Bayesian EWAS of smoking in Generation Scotland identified several novel loci and helped us generate a DNAm smoking proxy (mCigarette) that outperforms existing predictors (tested in The Lothian Birth Cohorts and ALSPAC)

GWAS of smoking in n=17k from Generation Scotland (unsuprisingly) showed not much. Hwr, GWAS of epigenetic smoking (n=17k, GrimAge smoking score) did! Comparison with GWAS of measured smoking (n=131k) in the middle plot.

The largest ever genome-wide association study on osteoarthritis has advanced understanding of the disease and laid the groundwork for developing more effective and personalised therapies that could transform osteoarthritis care: edin.ac/43HK39g Helmholtz Munich | @HelmholtzMunich Generation Scotland

In response to a recent Guardian article about why approved researchers in China can access our data, we've provided some additional information for our participants, including how we follow Government guidance on who can use UK Biobank. Please read: ow.ly/m4x050VAIzp

Bowel Cancer Awareness Month (1-30 April) is encouraging the sharing of experiences and symptoms — with Scotland’s researchers supporting the drive for treatments through diverse trials. #PassItOn Read the full story 🔗 nhsresearchscotland.org.uk/news/scottish-…

🔒 Curious about Trusted Research Environments (TREs)? Join us for our first TREvolution collaboration cafe: What do you want from a SATRE? Standardised Architecture is shaping the future of secure research in the UK! Sign up now ⬇️eventbrite.co.uk/e/trevolution-… UoD Medicine Alleviate

TW: Severe M.E. “the data backs up what many people with ME/CFS say: that they feel invisible and ignored.” - Professor Chris Ponting 🚨 Please note that this article is behind a paywall

Massive multi-ancestry GWAS resource for 1,167 clinical traits & diseases in 6 global biobanks (n=1,789,365) 👉29,139 locus-trait pairs 👉2,624 non-overlapping loci across the genome 👉associated with 6 traits each (median) 👉colocalization across traits for 72% of loci [1/3]

Nothing seems to have bigger impact on your plasma proteome than the use of hormonal contraceptives. Often misconstrued as age and sex effects, and I'm wondering if we really understand all health implications. nature.com/articles/s4385…

A consultation on a Long Term Conditions Framework lays out Scottish Government plans to shift away from a condition-specific focus, to bringing together all conditions under a single policy umbrella to improve early diagnosis & access to treatment, care & support. healthandcare.scot/stories/4134/l…

📣New Preprint: Protocol for Depression Genetics in Africa (DepGenAfrica), supported by Wellcome osf.io/preprints/osf/…

SAIL Data Reveals Link Between Shingles Vaccine and Reduced Dementia Risk 🚀🧠 New research published in nature finds compelling causal evidence that the shingles vaccine lowers dementia risk - using data from the world-renowned SAILDatabank. 🔗 saildatabank.com/sail-data-reve…

The Generation Scotland team were joint winners of the CMVM team award. Well done everyone!

Day one at the Scottish Dementia Research Consortium (SDRC) conference in Edinburgh today #ActiveVoice #SDRC2025 Members took this opportunity to launch the latest Active Voice Annual Report download your copy now 👇 bit.ly/3SmW0dv

Today’s World #OvarianCancerDay As someone who has endometriosis, PCOS, ovarian cysts & has had surgery to remove cysts & organs in the past I’m forever grateful I was lucky enough to receive treatment So to all medical staff & health researchers THANKS gen.scot

Our new sex-stratified #GWAS meta-analysis of major depression is now available as a pre-print in medRxiv medrxiv.org/content/10.110… A thread 🧵: QIMR Berghofer

Who benefits from antidepressants? New research from IoPPN (Dr Cathryn Lewis, Chris Lo 💊🧬🧠) shows how measuring antidepressant ‘switching can help scientists and clinicians understand why antidepressants work for some people and not for others kcl.ac.uk/news/who-benef…

Starting autumn, we will have a new #PhD position available in #Microbiology, to use spatially resolved #Metaproteomics to study metabiolic interactions in the gut #microbiome. Reach out if interested, or forward of you know anyone who might! tinyurl.com/2v982faj

Thanks BBC Scotland News for highlighting the importance of getting two doses of the MMR vaccine as protection against measles as the number of cases rises globally. Find out more about the MMR vaccine on NHS Inform⬇️ bbc.in/4dDKNzc

It's Blood Donor Week in Scotland, leading up to World Blood Donor Day on Saturday 14 June. 🎉 We'll be sharing news, amazing stories from donors, patients, and clinicians. Please help by signing up to become a Blood Donor on this special week. ❤️ scotblood.co.uk/news/bdw-25-la…