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Too much of a good thing is a bad thing, even for 'greedy bad guys'... Nature Reviews Cancer has just published a research highlight on our recent work published in Cancer Discovery. Check out this interesting piece from Nature Portfolio: nature.com/articles/s4156…

Multicellular Bacteria Evolve Defenses that Resemble the Immune System the-scientist.com/multicellular-…

New preprint from the lab! Thays de Oliveira noticed that activity of the Pseudomonas aeruginosa quorum sensing regulator RhlR is higher at 25°C than at 37°C, and found indications that such a lower temperature promotes its affinity for its C4-HSL ligand biorxiv.org/content/10.110…

Finally our Psp system paper is out: journals.asm.org/doi/epdf/10.11… Apart from uncovering manifold ramifications of the Psp system in membrane dynamics going back to the LUCA, it presents some new signaling paradigms: 1. the HAAS-PadR systems as an analogue of 2-component signaling

the-scientist.com/multicellular-… Among other things, talks about Reverse transcriptase-based diversifying FGS domain systems that we first identified as key players in bacterial antiviral defense with analogies to animal mutagenesis of antigen receptors.

Baby's first pre-print! The story I've been working on for the past 5 years as a postdoc. In short, I discovered (another) new protein 💅 that catalyzes lipoprotein N-terminal modification, now called Lnb in Bacteroides!

We're thrilled to share our new preprint: "Evolutionarily Conserved Principles of ESCRT-III-Mediated Membrane Remodeling Revealed by a Two-Subunit Asgard Archaeal System." biorxiv.org/content/10.110…

Wolbachia-mediated Cytoplasmic Incompatibility, transposons and other entanglements Our new collaborative work with ZhangLab_SLU lab is out. It investigates the fascinating phenomenon of the genomic basis of Cytoplasmic Incompatibility (CI) and its ultimate origins. This

Introducing the 😱OMG dataset and 🤖gLM2! OMG is a massive Open MetaGenomic corpus totaling 3.1Tbp of data and 3.3B proteins. We train gLM2, the first mixed-modality genomic language model, on OMG. 1/🧵 #BioML #AI4Science

Multiple Protein Structure Alignment at Scale with FoldMason biorxiv.org/content/10.110… github.com/steineggerlab/…

Coming soon: A "cheatsheat" of some of the widespread anti-invader(e.g., antiviral) molecular immune processes and their sharing across the superkingdoms of Life. Each protein structure is a real rendering of an actual exemplar. The image is divide into three columns representing

Our new article, “The Prokaryotic Roots of Eukaryotic Immune Systems,” is out. Immune factors from both prokaryotes (e.g., restriction-modification, CRISPR/Cas systems) and eukaryotes (antibodies) have been central reagents for the very emergence of modern biochemistry and

Excited to share our latest manuscript in which we analyzed 10,000 Salmonella genomes, identifying 128 T6SS effectors, including 45 new toxin domains (STox). We also characterized STox15, a lipid-targeting NlpC/P60 member. #Salmonella #T6SS biorxiv.org/content/10.110…

Growing roles for the NlpC/p60 clade of the Papain-like fold in lipid biochemistry. Nice collaboration with Ethel (Ethel Bayer Santos) and Robson's (Robson F. de Souza) labs. Gianlucca Nicastro

New paper online PNASNews! Great collab with Vikram Alva, Pohlschroder Lab, Amy Schmid and inspiring team work within the Bisson lab. PNAS: shorturl.at/tzNqn Preprint: shorturl.at/Wi58N Blurb: shorturl.at/vMZsZ highlights below (1/4)

Started teaching again! This time decided to try use #claude (Anthropic) and CodeSandbox for hosting to implement an interactive GREMLIN (Potts) model (w = coevolution, b = conservation) to show students how you go from MSA to contacts! 9kssnq.csb.app

Phenotypic heterogeneity may be ACTIVELY generated (not just passively by stochastic gene expression) in a population of sporulating #Bacillus subtilis, says Updegrove et al. A new sporulation pathway with 2 proteins of previously unknown function... science.org/doi/epdf/10.11…

🦠➗OUT NOW - PcdA promotes division plane selection in #Staph by Kumaran Ramamurthi Félix Ramos-León @braf_phd Vivek Anantharaman Amany M. Missiakas Lab CambergLab Aravind group @NCIResearchCtr nature.com/articles/s4156…

Extracellular Calcineurin-like phosphoesterases foster and signal altruistic behavior in bacteria This new work with Kumaran Ramamurthi Vivek Anantharaman and colleagues uncovers a new role for extracellular calcineurin-like phosphoesterases in bacteria. The calcineurin-like

My lab and Chuck Farah's at the University of São Paulo (USP) are seeking a postdoc to join an exciting project focused on applying structural biology to novel and unexplored targets in antibiotic discovery.