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Great work from Zahra shirzadi, PhD and the Harvard Aging Brain Study team in JAMA Neurology showing that WMH volume may be closely related to amyloidosis & neurodegeneration.

Very happy to share our new work in JAMA Neurology, showing that ApoE4 triggers earlier and faster amyloid-related tau spreading. Thus, Anti-amyloid therapies may need to come earlier in E4 carriers to prevent tau. Huge thanks to Anna Steward and my team! doi.org/10.1001/jamane…

Fantastic 3 days at #hai2024. Super grateful to receive the Young Investigator Award. Special thanks to Rachel Buckley 🐨🇦🇺🐨 Tobey Betthauser Prashanthi Vemuri for the prep and to all HABS friends Roos Jutten Michelle Farrell Stephanie Schultz @RoreBole @markdbm Wendy Yau Justin Sanchez Prokopis Prokopiou 💫💫

Thrilled to see Nature Medicine covering our work. Thank you! nature.com/articles/d4159…

Excited to share our latest paper in Brain, showing low VEGFA and high PGF in plasma were associated with faster cognitive decline in preclinical AD through accelerated tau pathology. Special thanks to co-first author Hyun-Sik and the Harvard Aging Brain Study team and participants!

Read our recent article on “Vascular contributions to cognitive decline: Beyond amyloid and tau in the Harvard aging brain study” JCBFM journals.sagepub.com/doi/abs/10.117…

How do #neuromodulation interventions affect #cognition? Our new Nature Reviews Psychology paper discusses the cognitive effects of #rTMS, #DBS, and #ablation in individuals with psychiatric and neurological conditions. nature.com/articles/s4415… Nir Lipsman Sunnybrook Health Sciences Centre @DoctorAndySmith

Spending time with Dad and appreciating his handy work #Spring

Looking forward to discussing my postdoctoral work on using remote, digital cognitive testing to examine previously understudied cognitive paradigms such as #practice effects and #intraindividual variability as promising cognitive markers in preclinical #Alzheimer’s disease.

Excited, grateful and THRILLED to receive a K99/R00 Pathway to Independence Grant NOA The National Institute on Aging (NIA). This project will investigate how hormones influence the downstream accumulation of Aβ & tau pathology. Indebted to outstanding mentors and colleagues for their unwavering support ✨

1/ Now out in Nature Communications with Andrea Luppi: our systematic evaluation of fMRI pipelines for functional connectomics! Wondering how to pick from the hundreds of unique pipelines when applying network neuroscience methods to your data? Find out here: rdcu.be/dJSsw

Lots of fun speaking at the first ever Brain Health Series in Boston, organized by incredible colleagues Anna Bonkhoff, MD Valentina Perosa. Recording on request!

I am excited to share our work, out now in The Lancet Neurology, showing cell-based measures of gamma-secretase activity and amyloid production predict clinical, cognitive and biomarker features in autosomal dominant AD. Link to paper: tinyurl.com/ye2a3d5u Alzheimer's Association #AAIC

An inspiring week at CTAD 2024. I had the pleasure of presenting our work on sex differences in Alzheimer’s disease pathology and discussing how this difference may influence the efficacy of cutting edge treatments! Harvard Aging Brain Study Rachel Buckley 🐨🇦🇺🐨

Our latest study out today! Findings reveal PSEN2 variants with known PSEN1 homolog variant show abnormal Aβ production patterns strongly correlated with age at symptom onset, while non-homologous PSEN2 variants often exhibit wild-type-like Aβ ratios doi.org/10.1002/alz.14…

Excited to share our Framingham Heart Study paper in ANA Journals!🧠 Sex-specific links between stroke risk factors and subclinical vascular brain injury support tailored prevention strategies in aging.👇doi.org/10.1002/ana.27… Big thanks to Sudha Seshadri, MD, Alexa, Matt, Rachel Buckley 🐨🇦🇺🐨 & team!

Thank you to HAI for a travel scholarship The Rainwater Charitable Foundation Biogen Bristol Myers Squibb Alzheimer's Association #HAI2025Grateful

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Excited to share the first in a new series of my monthly podcasts - a new way to engage our American Academy of Neurology members on the topics of strategic importance for the organization, for the field of #Neurology, and for our mission of promoting #BrainHealth for all. 💚 Let’s get to work!