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I have joined the list of laboratories that offer help to displaced researchers from Ukraine. If you work in a related area (DNA metabolism, biochemistry), please do get in touch. I hope Swiss authorities will facilitate relevant permits IRB_Bellinzona SEM EDA - DFAE

Great opportunity for doing cutting edge research on one of the hottest topics in gene editing and gene therapy at the moment: delivery!

Attention all MRE11 complex fans: Sequence and chromatin features guide DNA double-strand break resection initiation: a new paper from R. Gnuegge & L. Symington of Columbia Medicine, with contributions from our lab including Giordano Reginato of IRB_Bellinzona authors.elsevier.com/c/1gkk33vVUPNx…

Here is our preprint on the mechanism of DNA unwinding by MCM8-9 and HROB. Thanks to everyone involved, above all Ananya Acharya on our end and Alberto Ciccia, Ralf Seidel and Raphael Guerois for invaluable contributions. A summary follows: (1/n) biorxiv.org/cgi/content/sh…

Congratulations to our own Issam Senoussi for winning one of the poster awards! ⁦Fusion Conferences⁩

Here is our latest paper together with Raphael Guerois on the MCM8-9 helicase complex and its activation by HROB. Congratulations to Ananya Acharya and many thanks to Alberto Ciccia and Ralf Seidel labs nature.com/articles/s4146…

Check out our latest paper showing that HLTF removes Cas9 from DNA, explaining phenotypic differences when using the two Cas9 nickase variants. Important for gene editing! Thanks to Giordano Reginato & Rosaria and @MartinJinek Taekjip Ha andre nussenzweig lab nature.com/articles/s4146…