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Excited to get this work out! Check out my inaugural first author paper on our method for the conversion of pyrimidine to pyrazole a out now in J. Am. Chem. Soc..

Skeletal Editing of Pyrimidines to Pyrazoles by Formal Carbon Deletion Sarpong Group UC Berkeley College of Chemistry Total Synthesis Total Synthesis and Methodology Highlights #Editing #Pyrimidines #Pyrazoles #Carbon #Deletion pubs.acs.org/doi/10.1021/ja…

Grateful to have been a part of this awesome team and work with #MerckChemistry and the Sigman Lab! Excited to share my new first author paper on an isotopic labeling strategy for nitrogen heteroaromatics using skeletal editing. Check it out on ChemRxiv: rb.gy/990eaq.

15N Incorporation into pyridines via NTf-Zincke imine intermediates now on ChemRxiv . Congrats to Hillary, David, Marie, Kaila, and Jeff from my lab: tinyurl.com/ytbh3nem See related work from Sarpong Group Sigman Lab/ Smith/Feuillastre-Audisio

Fourth year Logan Bartholomew, placed 2nd in the poster session for his great poster on his recent 14N-to-15N skeletal edit of nitrogen heteroaromatics work. Congrats Logan! We’re so proud of you! 5/5

Great day meeting at College of Chemistry for the #MerckChemistry lecture yesterday. Enjoyed the panel discussion in the AM with students!

Congrats to Logan Bartholomew , Samantha Kraus BS and our collaborators at #Merckchemistry and the Sigman Lab on the publication of our work on 14N to 15N exchange in azines in JACS! pubs.acs.org/doi/10.1021/ja…

Our azine N-isotope exchange is out now in J. Am. Chem. Soc.! Excited to share this story with a few twists in the Sarpong Group with the Sigman Lab and Charles Yeung from #MerckChemistry. Big thanks to Samantha Kraus BS, Lucas Karas, and this awesome team. bit.ly/15Nie

14N to 15N Isotopic Exchange of Nitrogen Heteroaromatics through Skeletal Editing | Journal of the American Chemical Society University of Utah Utah Chemistry UC Berkeley College of Chemistry Sigman Lab Sarpong Group #Hetarenes #Skeletal #Editing Total Synthesis and Methodology Highlights pubs.acs.org/doi/10.1021/ja…

Guilty as charged

Our investigation into the photomediated ring contraction of saturated heterocycles is out in J. Am. Chem. Soc.! Excited to finally share my inaugural 1st author, multi-part story that blends synthesis, mechanistic & wavelength-dependent insight, and computations. tinyurl.com/hccapy9d

My total synthesis of baphicacanthcusine A is out now in Angewandte Chemie. It has been a fascinating journey learning about these unique molecules and I’m really proud to tell this story! onlinelibrary.wiley.com/doi/10.1002/an…

Ever thought about quantifying molecular complexity? We wrote a Perspective on how modeling this fascinating concept can lead to new insights in synthetic chemistry. Check it out in Nature Reviews Chemistry! 🎉 Sarpong Group nature.com/articles/s4157…

We’re excited to share our quantitative assessment of the potential impact of skeletal edits, now on ChemRxiv! This cheminformatic platform was developed with Lucas Karas from Sigman Lab and Reilly Eason & Charles Yeung at #MerckChemistry. tinyurl.com/yc4jev9k

The final chapter of my PhD with Sarpong Group at College of Chemistry is published! Check out our full story of how we approached the synthesis of Daphniphyllum alkaloids inspired by molecular complexity scoring, out now in J. Am. Chem. Soc. 🎉 pubs.acs.org/doi/10.1021/ja…

To round out our work on these photomediated ring contractions of saturated heterocycles, I'm excited to share this collaborative story about uncovering interesting enantioselectivity trends in this system, out now in J. Am. Chem. Soc.!

Congrats to Logan Bartholomew, Sojung Kim, Yusuke and collaborators Macroarc, Gilead Sciences, Merck on our indazole to benzimidazole conversion  onlinelibrary.wiley.com/doi/10.1002/an… coordinated with Leonori Lab  onlinelibrary.wiley.com/doi/10.1002/an…

This project was a ton of fun to put together and wouldn’t have been possible without the tremendous efforts of this team. Check out our now-published cheminformatic platform for skeletal edit development prioritization below! bit.ly/3Dq9Mbo