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Question to gene regulation folks: What was the earliest paper showing distance dependence of enhancer activity? The earliest I could find is Moreau et al. NAR 1981, which showed that moving the SV40 enhancer further away from the promoter decreases its expression.

Super excited to present today at Hilde Mangold Symposium !!! If wondering how forelimbs(arms) and hindlimbs(legs) grow at different times in our body (and other mammals) come to see my talk ! #InTimingWeTrust, #SDB2024

Loss of ETS sites in the ZRS enhancer of Shh has been linked to limb reduction in snakes. Here is another example of independent ETS site mutations in the ZRS linked to fin reduction in some lungfishes. Congrats to all authors of this tour de force study! nature.com/articles/s4158…

Happy to share CREsted, our latest package on enhancer modeling! CREsted allows for training sequence-based deep learning models from scATAC-seq data, enhancer decoding and enhancer design through a variety of methods. Check out the GitHub here: github.com/aertslab/CREst…. [1/9]

This is a fascinating article about the discovery of the first transcriptional activator gene. Jacob, Monod and others were skeptical of the positive control model. Of course today we know that it's much more widely used mechanism than repression. dx.doi.org/10.1534/geneti…

Excited to share the white paper for the IGVF Consortium, supported by National Human Genome Research Institute Deciphering the impact of genomic variation on function rdcu.be/dSZdm

My favorate piece of my postdoc work is published! We fused our favorite TFs with a deaminase domain that induces point mutations in DNA, mutagenizing TF binding sites across the genome. Will be a great reagent for exp. evo., as its name suggests :) academic.oup.com/mbe/article/41…

Enhancers have piqued the interest of researchers since their discovery in the early 1980s. In his lab UC Irvine, geneticist Evgeny Kvon studies how they regulate gene expression during mammalian development. Learn more in this interview: bit.ly/3MtvoES

First look at the genome sequence of Greenland shark to find possible clues that could explain their mind-boggling extreme lifespan of up to 400 years. - 70% of the genome is repetitive elements - many uniquely duplicated genes, many related to DNA repair pathway - p53 is not

We're cooked.

We ❤️ MODs! Want an easy way to support model organism databases? Cite them! Depending on the #zebrafish data you retrieve from ZFIN, you can show your support by using one of the formats below:

We had a spectacular Structural Birth Defects/Anomalies meeting at Baltimore the past two days. Rolf_Stottmann and Irene Zohn were the co-organizers and, along with the organizing committee did an amazing job. Society for Developmental Biology provided logistical support and were amazing as always. /1

Please RT! UT Dallas Biology UT Dallas is hiring MULTIPLE faculty. jobs.utdallas.edu/postings/27454 There are 3 priority areas: biochemistry, computational biology, and neurobiology, but we'll also consider ALL research areas that address broad & significant questions in Bio/Biomed sciences.

Please join us for our 2024 Department of Pharmacology Distinguished Alumni Award and Lecture J. Craig Venter, Ph.D. Date: October 8th, 2024 at 12:00 noon (PST) Location: Biomedical Sciences Building, Liebow Auditorium, 2nd floor

Delighted to be at American Institute of Chemical Engineers (AIChE) - American Institute of Chemical Engineers annual meeting at San Diego to meet friends/colleagues and explore exciting science and engineering. We are organizing three ‘Faculty Candidate Sessions’ within Area 15 (Food, Pharmaceuticals, and

Updated VISTA Enhancer Browser, 7 years in the making, out in Nucleic Acids Res! >4,500 transgenic in vivo enhancer experiments for all your developmental biology, human variation and #evodevo needs. enhancer.lbl.gov #enhancers #embryos doi.org/10.1093/nar/gk…

A red-yellow pigment dial in parrots: Was fortunate to take part in this cool story by my colleague Corbo Lab at Washington University in St. Louis, with Miguel Carneiro, Roberto Arbore, @JindraBrejcha, Miguel Araujo, et al. A non-coding SNP tunes an enzyme to control feather color: science.org/doi/10.1126/sc…

Interested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day on Friday 4/25. All talks will be live-streamed (no registration required) at satijalab.org/scgd25

Our work on mesoderm development in 2D gastruloids is now published in Nature Methods: nature.com/articles/s4159…