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Designing DNA-binding proteins shouldn’t require structures. ❌🧬 With DPAC, we align protein and DNA language models via contrastive learning -- then use simulated annealing to design new binders straight from sequence! 🔀 📜: biorxiv.org/content/10.110… 💻: github.com/programmablebi…

Our paper describing an RNA-LNP prime editing strategy for treating phenylketonuria was published today in Nature Biomedical Engineering (1/7) nature.com/articles/s4155… Gerald Schwank UZH Science University of Zurich Kinderspital Zürich ETH Zurich

I am beyond grateful to see this one out! András Tálas, Eleonora and Gerald Schwank put so much work in to revise this story. Please check out how we achieved prime editing in vivo using LNP. 🧵:

CRISPR-BEasy, our web tool for designing tiling libraries for base editing screens, was published last Friday in NAR (sorry, I am late). Goal: To make base editing screens accesible to all! Quick thread below with key features crispr-beasy.cerc-genomic-medicine.ca/# academic.oup.com/nar/advance-ar…

🚨 Our work on optimizing single-stranded DNA donors with Cas12a binding moieties is published at Molecular Therapy Nucleic Acids! Since the preprint, we added two super interesting findings. Short 🧵👇 (1/4) cell.com/molecular-ther…

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with Walter Isaacson & Christiane Amanpour on Amanpour and Company, airing on PBS tonight at 11 pm ET, and on CNN International earlier today. Pls share! youtube.com/watch?v=8YhJM6…

Maarten van den Hoogenhof found a specific way to improve cardiac function in RBM20 cardiomyopathy. CAMK2 inhibition might become the first tailored therapy for a Dilated Cardiomyopathy (after mavacamten for Hypertrophic Cardiomyopathy): biorxiv.org/content/10.110…

News of the first infant treated with a custom-built CRISPR therapy electrified the field But it raised a hard question: How do we assure baby KJ is not a one-off? Can personalized gene editing be given to thousands? It won't be easy but it is possible: statnews.com/2025/05/26/wha…

🚨New paper🚨 Excited to share our latest on nature today: The PIVOT PENALTY in research. nature.com/articles/s4158… More than five years in the making. Key finding: The impact of new research steeply declines the further a researcher moves from their previous work.

This is an incredible progress story An aggressive type of cancer (Philadelphia chromosome–positive acute lymphoblastic leukemia) used to carry a dismal prognosis, with 50% of patients dying in a year New therapies have transformed it to a cancer that most people are cured of

Our latest story is now online nature! We discovered a phage defense system that deploys kilobase-long DNA homopolymers to protect against viral infection. Congratulations to all authors, and to the Wiedenheft Lab for a fun and fruitful collaboration! nature.com/articles/s4158…

We are pleased to have been able to do our bit in this impressive work led by Michela Milani, Alessio Cantore and Luigi Naldini, in which we have demonstrated that in vivo gene therapy can recover bone marrow failure in a Fanconi anemia mouse models. 👏👏👏👏👏🧬🧬🧬🧬🧪🧪🧪

In the ocean, a single-celled organism travels ~50 meters vertically by rapidly inflating its body with water. The dinoflagellate, Pyrocystis noctiluca, does this by swelling six-fold in size in just ten minutes. This fast expansion drops cell density. When the cell becomes less

Excited to share my last major PhD work from the Sternberg Lab. We discovered a mechanism that initiates transcription at programmable sites, without requiring promoter sequences - a novel mode of transcription regulation in bacteria.

🤔 How do you get an LLM to reason like a CRISPR pro—or any top scientist? By training it on real expert conversations. 🛠️ What we built • An automated pipeline that distills learning signals from 10 + years of genomics discussions • Genome-Bench: 3,000 + curated Q&As on

1/14 On behalf of the amazing team in Jonathan Weissman's Lab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out rdcu.be/eq975

🚨NEW - In vivo CAR T cell generation to treat cancer and autoimmune disease Capstan Therapeutics direct delivery of mRNA-encoded CARs to CD8+ T cells in mouse & NHP models shows tumor control not only in blood, but also tissue. Immune reset seen at B cell recovery science.org/doi/10.1126/sc…