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1/ We are excited to share our report in Journal of Experimental Medicine showing that about 40% of cases of #WestNilevirus (#WNV) encephalitis are due to pre-existing auto-Abs neutralizing type I IFNs, making WNV encephalitis the best understood human infectious disease (rupress.org/jem/article/22…).

One fantastic collaboration with Casanova Lab, Adrian Gervais, @ShenYingZhang, and all the co-authors - just go through the thread to discover more !

In Journal of Experimental Medicine, Adrian Gervais et al. show that auto-Abs neutralizing type I IFNs and pre-existing infection underlie ~40% of cases of West Nile virus (WNV) encephalitis. bit.ly/3qZIeDh Aurelie Cobat Shen-Ying Zhang Casanova Lab Alessandro Borghesi

Very happy to share my 1st paper as 1st author! Thanks to all our amazing collaborators for this fantastic journey. More to come! #WNV #autoAbs 🤩Alessandro Borghesi Casanova Lab

Félicitations à Casanova Lab pour leur nouvel article dans Journal of Experimental Medicine ! Après leur rôle dans les formes sévères de COVID et de grippe, ils éclairent le lien des autoanticorps avec les formes sévères d'encéphalites dues au Virus du Nil Inserm Assistance Publique – Hôpitaux de Paris (AP-HP) Université Paris Cité

Screening for auto-Abs neutralizing type I IFNs is key to design prevention strategies. Check out doi.org/10.1038/d43978… Adrian Gervais Luisa Barzon Shen-Ying Zhang Casanova Lab Journal of Experimental Medicine

I will have the great honor of presenting part of my PhD work at the Encephalitis International 2023 meeting next December, in London. Thanks a lot for the amazing opportunity! 🤩

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#Encephalitis2023 is now underway. @encephalitisava & Dr Nick Davies are leading the first session. Speakers include Dr Tarun Dua World Health Organization (WHO) , Dr Sophia Michael, Dr Christine Strippel, Adrian Gervais & Dr Tina Damodar. Excited to hear what they have to say about #encephalitis research.

I was delighted to share my work about West Nile virus encephalitis at the @Encephalitis2023 in London! And this is an honor to be awarded with the best platform presentation🙏 I met great people in with outstanding scientific level. Thank you Ava and the team! 🧠🧑‍🔬🤩

The title tells it all ! Severe West Nile virus and Sars-CoV-2 infections in a patient with thymoma and anti-type I IFN antibodies pubmed.ncbi.nlm.nih.gov/38976510/

West Nile virus season in full swing in Europe Austria reports 7 West Nile virus infections after mosquito bites (Lower Austria, Burgenland), including 3 hospitalized with neurological symptoms. One imported from Hungary Several others under investigation ecdc.europa.eu/en/news-events…

🦟 5 cas d'infections à virus du Nil occidental ont désormais été rapportés dans le Var, et plus de 70 dans toute l'Europe (dont 8 décès). L'infection, par piqûre de moustique, est généralement asymptomatique mais elle peut provoquer de rares formes neurologiques graves. 1/3

About 10% of people who develop severe Covid have autoantibodies to Type 1 interferon, which doesn't get diagnosed. Now there's a simple assay. It's also relevant for other life-threatening viral illnesses, and these Abs exist in ~100 million people worldwide.

Thrilled to share my second first-author paper out in Journal of Experimental Medicine. We show that about 10% of severe tick-borne encephalitis cases are due to auto-Abs neutralizing type I IFNs. Thanks to all our wonderful collaborators!

We report here in PNASNews a simple assay to detect human type I interferon (IFN-I) deficiency. This test could revolutionize the diagnosis and management of patients with autoantibodies against IFN-I and inborn errors of immunity (IEI) affecting the IFN-I pathway!

1/ Excited to report in Journal of Experimental Medicine more about the causes and consequences of human autoantibodies neutralizing type I IFNs through the study of a rare disease: shorturl.at/cWcCa

Just published in Nature Communications! We show that Usutu virus is the only mosquito-borne flavivirus to resist ISG20-mediated inhibition, thanks to a unique domain in its 3'UTR that protects its genome from degradation. A project led by Jim Zoladek at IRIM. rdcu.be/dVMK1

The Phenocopies of IEI session at #ESID2024 features experts Steve Holland, Anne Puel, Ben Hale, Aude Magerus, Sophie Hambleton, and Adrian Gervais exploring how similar phenotypes emerge from different genetic causes. #IEI #ESID