🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/

🚀 Excited to share that I’ve joined Emory School of Medicine & Winship Cancer Institute of Emory University to launch The Berchuck Lab. Our research is focused on using liquid biopsy to improve outcomes for people living with cancer. We’re hiring for several key roles! Learn more & apply: theberchucklab.org

A beautiful night celebrating our friend/collaborator and scientist-extraordinaire Matt Freedman, the new David Goldstein Chair Dana-Farber. The Chair will focus on many aspects of Kidney Cancer Research Dana-Farber Lank Center for Genitourinary Oncology

Our single-cell, pan-cancer analysis of open chromatin in human cancers, done in collaboration with TCGA and the Chang and Corces labs (among others including Illumina), is out in Science today. Congrats to Laksshman Sundaram and all authors! science.org/doi/10.1126/sc…

Last chance to register for the Experimental & Translational Hematology Meeting in Krakow, 11-12 October! Don’t miss out on incredible speakers and share your data. Register for free bit.ly/4g1uPQ8 See you in Krakow! #Hematology #Research

Met a true legend today.

Reinvigorated after this incredible conference put together by Krzysztof and team! Fun discussions with new and old friends and inspiring talks by legends in the field. Looking forward to the next event and the pioneering research coming from the Szade lab!

Happy to share our new work describing DESynR genes! The evolution of new human protein-coding genes relies on repurposing protein domains from ancestral genes, rather than de novo sequence creation. New genes evolved from old parts, and while we have methods that enable

1/ This is the next chapter of a story about courageous patients and their families, of multidisciplinary teamwork, and hard-fought steps forward to effective therapy for #DIPG #DMG, a universally lethal cancer of the brain and spinal cord. 🧵nature.com/articles/s4158…

🎉 Excited to share our new findings in Marc Andre! 🎉 Bone marrow transplants (BMT) require conditioning, but this process is harsh and damages the endothelial niche in bone marrow. This niche is essential for hematopoietic stem cell (HSC) function and needs rapid regeneration. 🧵

Happy to announce my next career step - I’ve launched my independent research lab at Dana Farber! If you are a trainee interested in ambitious projects at the intersection of chemical biology and cancer biology, please reach out! gibsonlab.org

Quantifying biophysical relationships in the HSC niche. Remarkable study by Szade lab!

The statistics of early-onset colorectal cancer are sobering but I always find narrative more humanizing than numbers so let's put a face to this scourge Brinlee (here👇with her husband Parker and some middle-aged oncologist) was 21 when she first experienced hematochezia 🧵

Stunning paper Parkinson’s starts in kidney nature.com/articles/s4159…

This is so cool. Reads like the plot of a sci-fi movie.

I’m excited to share my work over the last few years with Jason Buenrostro! Chronic inflammation creates an epigenetic memory in colonic stem cells, priming them for tumor growth: tinyurl.com/ColitisNagaraj…. Here’s a walkthrough of what we found (🧵)

We trained a genomic language model on all observed evolution, which we are calling Evo 2. The model achieves an unprecedented breadth in capabilities, enabling prediction and design tasks from molecular to genome scale and across all three domains of life.

I am delighted to share a manuscript long in the making, elucidating the forces that shape metastatic adaptation PDAC using scRNA-seq across multiple organs from a rapid autopsy combined with a powerful new clonal phylogeny inference algorithm biorxiv.org/content/10.110…

Fascinating insights into cell fate reprogramming and dependence on proliferation history. Lots to take away for cancer epigenetics and cell state biology.

Today we announced positive results from the pivotal Phase 3 study of investigational Orca-T versus conventional allogeneic stem cell transplant for the treatment of hematologic malignancies. The results will be presented at the 51st Annual Meeting of the EBMT on April 2, 2025.