Guofangzhang (@guofangzhang) 's Twitter Profile
Guofangzhang

@guofangzhang

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calendar_today20-07-2009 23:45:08

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Pathophysiological mechanisms of complications associated with propion... sciencedirect.com/science/articl… Our first comprehensive review on pathophysiological mechanism of propionic acidemia (PA) since our group started this project. There are still a lot to learn about PA apparently.

Guofangzhang (@guofangzhang) 's Twitter Profile Photo

rdcu.be/dlKOq Dr. You Wang published a informative review on Prevalence of propionic acidemia in China. This is excellent review work. Congratulations to Dr. Wang!

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How does fasting impact propionic acidemia? Contrary to traditional belief, a 23-hour fast actually improves metabolic stress in a mouse model of propionic acidemia. For more details, please refer to our recent publication in Communications Biology. rdcu.be/dJmO9

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rdcu.be/dNz2F Our recent paper strongly suggests that propionate is a major source of propionyl-CoA in the heart. Circulating propionate levels play a significant role in cardiac dysfunction in propionic acidemia. rdcu.be/dNz2F

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Discovery of fuel switch in PCCA mutated hiPSC-CMs. Our recent collaborative work on propionic acidemia with Drs. Eva Richard and Lourdes R. Desviat has been published in Cellular and Molecular Life Sciences (2025) 82:137. doi.org/10.1007/s00018…

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JCI Insight - Dissecting the effect of mitochondrial BCAT inhibition in methylmalonic acidemia insight.jci.org/articles/view/… Blocking BCAA metabolism does not appear to reduce propionyl-CoA synthesis or improve metabolic abnormalities in MMA, and the same seems to apply to PA.