INPP4B promotes #PDAC aggressiveness via PIKfyve and TRPML-1–mediated lysosomal #exocytosis, say Golam Saffi, Leonardo Salmena et al. SalmenaLab Pharm & Tox hubs.la/Q02KNsTJ0 #Cancer #Migration #Organelles #lysosomes

#MembraneTrafficking seminars are back! Join Fèlix Campelo Francesca Bottanelli and me for an exciting lineup of speakers in our Sep-Dec '24 season. Fascinating science covering protein secretion, lysosome-secretory pathway crosstalk, lipid trafficking...

Great to finally see this online J Cell Science journals.biologists.com/jcs/article/13… I hope it is a great resource for everybody embarking in proximity labelling #masspec experiments! I promise all plasmids will be on Addgene in the next few weeks! Alexander Stockhammer Freund_Lab@FUB

Last chance to register for the Biochemical Society Membrane Contact Sites meeting in Edinburgh in September! eventsforce.net/biochemsoc/fro…

#membrane seminars are back this week! Do not miss this double bill with stellar early career researchers! ⁦Anup Parchure⁩ Yale Cell Biology and Miguel Gonzales-Lozano from the Harper lab ⁦⁦@HarvardCellBio⁩

So happy to finally see this out! Great work by first authors Alexander Stockhammer and Petia Adarska which have shown that cargo flow along post-Golgi routes is driven by a key maturation step where compartments defined by ARF1 nature into recycling endosomes nature.com/articles/s4155…

PI3K dependent rearrangement of the actin cytoskeleton following the addition of Class I PAK kinase-inhibitor. Please read about it in our pre-print!

Amazing work from joe on the excitability of the actin cortex and the role of p21-activated kinases (PAKs) in this process. Go check it out! I have seen this work evolve over the years and it is great that it can finally be shared with the community.

We are looking for a #PhD student to study #MolecularMachines driving #membranetrafficking by #cryoEM #cryoET #temtomo. Image processing fans are particluarly welcome.

Freeze Fracture EM is still the king on the block for visualising lipids in the PM! A pity that it is such a niche and challenging technique but would be interested to know how other PM lipids (PI(4)P, PS, PI(3,4)P2, PI(3,4,5)P3) distribute compared to good old PI(4,5)P2

Every programmer that is collaborating with cell biologists expects them to learn „just some basic coding“. Fair enough. But how about programmers learning some basic cell biology? Not too difficult to grow some cells and take pictures of them under the microscope. Is it?

Twitter has been transformational for my as early career researcher to connect with other scientists as well as journal editors. However, it has become a very stale environment of self promotion without human discussion. So find me on bluesky and lets rebuild our community

If you’re interested in immune cell metabolism I’m recruiting a PhD student. Deadline: 17th Jan. findaphd.com/phds/project/e…

Incredibly honoured to have my first paper as PI highlighted in this collection! The idea was do a quick tool paper as start into independence and it turned out to be much more useful than I thought. Read about how to use recombinant biosensors to stain for lipids in fixed cells!

.Hannes Maib et al present a toolkit for visualization of phosphoinositides in fixed cells & tissue, enabling multiplex & super-resolution characterization of these signaling #lipid hubs.la/Q02_5lKD0 Part of the Year in Cell Biology: hubs.la/Q02_5l790 #CellBio2024

🚨Long term postdoc position available on the reconstitution of lipid kinases!🚨 Do you have a passion for protein reconstitution and lipid signalling? You will reconstitute lipid kinases to determine their kinetic regulation. jobs.ac.uk/job/DLW981/res…

First time playing around with single molecule STORM imaging of PI3P on endosomes using our recombinant biosensors. This was great fun with our new fellow Dr. Ruby Peters and I see lots of potential for this in the future!

Only 10 days left to apply! We are looking for a passionate protein biochemist for the reconstitution of lipid kinases. We have long term funding and you will be trained in the use of supported lipid bilayers. If you are interested just get in touch or apply directly!

We have a postdoc position available in our team to undertake a UKRI-funded project to develop a new cultured skeletal muscle model for studying glc metabolism and insulin action. jobs.cam.ac.uk/job/50597/ Inst Metabolic Science-Metabolic Research Labs Please RT. Please email if interested.

Joe Tyler joe, Anthony Davidson, Vassilis Koronakis & team find that inhibition of PAK activity leads to the production of PI(3,4,5)P3 at the plasma membrane & a dysregulation of the actin cytoskeleton. journals.biologists.com/jcs/article/13… Article: journals.biologists.com/jcs/article/13… #OpenAccess