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Thrilled to welcome Masahiro Nagano to the lab as a new post-doc with fellowships from JSPS and HFSP - Masahiro is interested in understanding 3D genome structure and function relationships during germ cell differentiation.

Excited to welcome Jack Toppen to the lab as a new graduate student who joins us from the MIT CSB PhD Program graduate program - Jack is interested in developing computational tools for understanding and modeling transcriptional bursting.

Congrats to @proteinnns, Hui Si, @clee_bio, Liau Lab on this new paper on LSD1 with imaging contributions from Domenic Narducci sciencedirect.com/science/articl…

We are thrilled to welcome Coco Wu to the lab as a new graduate student from the MIT Biology graduate program co-advised with Francisco J. Sánchez-Rivera - Coco is interested in exploring the relationship between DNA sequence, DNA looping, gene expression, and disease!

Check out Sarah's new review on bidirectional promoters: sciencedirect.com/science/articl…

Here's our new group photo taken by Michele Gabriele 🔬🧬📸

Excited to welcome Jacob Jacob Kæstel-Hansen as a new Novo Nordisk Foundation post-doc to the lab!

Congrats to Ava Ava Conyer on a fantastic MSRP poster presentation on the polycomb work she did together with Sumin Sumin Kim !

Bittersweet to say goodbye to Christos last week - Thanks for 2 fantastic years and all the best for grad school at Columbia!

Congrats to Nicholas Aboreden blobellab with RCMC contribution from Viraat Goel ASHansen Lab . Having recently worked on what we thought was a looping factor (ZNF143 biorxiv.org/content/10.110… ) it was amazing to work on a strong Enh-Promoter looping factor LDB1 biorxiv.org/content/10.110…

Congrats to Gavin Schlissel Pulin Li with single-molecule imaging contribution from Domenic Narducci ASHansen Lab Single-molecule imaging of hedgehog in morphogen gradients reveals a surprisingly complex diffusion mechanism: pnas.org/doi/10.1073/pn…

Come and see James' BATS talk today

Congrats to Viraat Goel James Jusuf et al. on new preprint in collab with @Irate_Physicist blobellab Leonid Mirny discovering transient microcompartments that connect enhancers and promoters in mitotic chromosomes: biorxiv.org/content/10.110…

Very grateful to NIH Common Fund for funding our Transformative Research Award #NIHHighRisk

Our preprint by Domenic Narducci and the companion preprint by deWitLab are now out in Molecular Cell ZNF143 is not a general looping factor and was identified as such due to a non-specific antibody. Instead it is TF with the longest residence time measured (to our knowledge)

Mostly on BlåSky but excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we perform absolute quantification of looping (e.g. this loop is present 3%). We quantify mESC 36k loops: <loops> are generally rare (2.3%). biorxiv.org/content/10.110…

Check out Masahiro Nagano's preview sciencedirect.com/science/articl… of a very cool paper from Tjalsma...Wouter de Laat: cell.com/cell-genomics/…

(1/n) New preprint from clarice Fan Fang Varshini Ramanathan in collab w Jie Liu Q: How do we get ultra-high-res 3D genome maps? A: New deep learning model, Cleopatra. Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps biorxiv.org/content/10.110…

(1/13) Thread on Matteo Mazzocca Domenic Narducci Simon Grosse-Holz Jessica Matthias new preprint Q: how does chromatin move? Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide some answers biorxiv.org/content/10.110…

Congratulations to Dr. Viraat Goel and Dr. Domenic Narducci, both new PhDs in Biological Engineering from the lab!