Hans Renata (@hanzyduzit) 's Twitter Profile
Hans Renata

@hanzyduzit

knowin' nothin' in chemistry but to be legit

ID: 797263358504423424

calendar_today12-11-2016 02:22:51

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"The fully modified RiPP product was named steromaze (30), as suggested by ChatGPT for an unusually complex polycyclic peptide with a steroid-like moiety." 😂

Hans Renata (@hanzyduzit) 's Twitter Profile Photo

We characterized the catalytic properties, substrate scope and structure of KslB, an unusual Pictet-Spenglerase with the ability to form 1,1-disubstituted tetrahydrocarbolines: chemrxiv.org/engage/chemrxi…

We characterized the catalytic properties, substrate scope and structure of KslB, an unusual Pictet-Spenglerase with the ability to form 1,1-disubstituted tetrahydrocarbolines: chemrxiv.org/engage/chemrxi…
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We made fostriecin with a chemoenzymatic strategy that *should* allow for many analogs. Some key features: substrate decoy + enzyme engineering for P450 oxidation optimization and late-stage Suzuki coupling in the presence of a labile phosphate. chemrxiv.org/engage/chemrxi…

We made fostriecin with a chemoenzymatic strategy that *should* allow for many analogs. Some key features: substrate decoy + enzyme engineering for P450 oxidation optimization and late-stage Suzuki coupling in the presence of a labile phosphate. chemrxiv.org/engage/chemrxi…
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Officially marking the 3rd time that nimbolide is made by someone affiliated with my lab (David Ryffel now a PD in my lab) 😎