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Jallet et al. explore and compare the transcriptomes of a large set of Brettanomyces bruxellensis yeast isolates with the goal of providing a deeper insight into the differential expression of coexisting genomes and their consequences. #G3Journal | bit.ly/47ncnNH

Latest preprints from the Schacherer Lab. Here, we used an old genetic trick and design - diallel cross - to teach us new things about genetic architecture of traits, and more precisely about gene expression variation doi.org/10.1101/2023.0… and doi.org/10.1101/2023.0…

Multi-SNP combination genome-scale metabolic models identify molecular mechanisms determining genetic interactions in a quantitative trait biorxiv.org/content/10.110… In this paper, we Srijith Sasikumar address how multiple SNPs of a quantitative trait interact... 1/4

Latest preprint from Schacherer Lab on translation variation across yeast genetic backgrounds! Interesting translation differences between introgression, HGT and canonical ORFs. Great work by Elie Teyssonnière and superb collaboration with Iwasaki_Lab_RIKEN - biorxiv.org/content/10.110…

We are pleased to share our paper, new in @sciencemagazine, on the scale, impact, and mechanisms underlying mutations arising in meiosis. Thanks to the team, collaborators, and colleagues! (1/2) science.org/doi/10.1126/sc…

Species-wide survey of the expressivity and complexity spectrum of traits in yeast. Latest article from us Schacherer Lab in PLOS Genetics journals.plos.org/plosgenetics/a…

Excited about our latest preprint on recombination variation between species. We found a recurrent loss of crossover interference punctuating the recombination landscape in yeast. Great job from Abhishek and nice collaboration with Bertrand Llorente! biorxiv.org/content/10.110…

Congrats Andreas Tsouris for his PhD prize from the Société de Biologie de Strasbourg SocieteBiologieStrasbourg for the work he has done within the Schacherer Lab! His work gave rise to some very nice results and papers: pubmed.ncbi.nlm.nih.gov/38355920/ pubmed.ncbi.nlm.nih.gov/38236897/ pubmed.ncbi.nlm.nih.gov/38190102/

Population-wide transcriptomes and proteomes reveal distinct genetic control of gene expression. Great work by Elie Teyssonniere and collaboration with Ralser Lab, Julia Muenzner, Pauline Trébulle. And much more to come on both levels of expression very soon… pnas.org/doi/10.1073/pn…

1/n I'm so very happy and excited that my main postdoc work is out now nature 😁 This was such a fun and rewarding project to work on - thanks Markus for letting me dive into the wonders of yeast and proteomics despite this being an almost 180° change from my PhD work.

After the species-wide transcriptomes, the quantitative proteomes of the 1,011-yeast collection with an interesting story on aneuploidy tolerance. Great work by Julia Muenzner, Pauline Trébulle, Ralser Lab and Judith Berman 💔, and happy to have contributed to nature.com/articles/s4158…

BioRxiv: Overview of the Saccharomyces cerevisiae population structure through the lens of 3,034 genomes dlvr.it/TDTPKR

New preprint from the Schacherer Lab! Here, we revisit the population structure somewhat. But the main objective is rather to have a resource for the community around 3,034 genomes, capturing ~93% of the genetic diversity of the S. cerevisiae species. biorxiv.org/content/10.110…

Latest article from Schacherer Lab on multiple independent losses of crossover interference during yeast evolutionary history. Superb collaboration with Bertrand Llorente as usual and great work from Abhishek and the whole team! dx.plos.org/10.1371/journa…

Our study, "Reconstruction of the human amylase locus reveals ancient duplications seeding modern-day variation," has just been published in Science. This thread will provide a brief overview of how gene duplications have shaped modern variation in the amylase locus.

First Schacherer Lab paper to start 2025! embopress.org/doi/full/10.10…

Since 2012, we've been running the Strasbourg Ekiden with Schacherer Lab. This is our 13th edition. And it's still just as fun!

📢 PhD position available within the Schacherer Lab. Application deadline - 05/31/2025. For more information, see haploteam.org or send me a message!

Very happy to share our latest work: The evolution of thermal performance curves in response to rising temperatures across the model genus yeast | now available in PNAS pnas.org/doi/10.1073/pn… Special thanks to my great co-author Stelkens Lab

Beyond happy to be an ERC AdG laureate! This milestone would not have been possible without the incredible work done in the past and the dedication of all current and former members of the Schacherer Lab CNRS Biologie Institut universitaire de France (IUF) #unistra x.com/ERC_Research/s…