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Computational Modeling of Ternary Complex Formation and Targeted Protein Degradation Mediated by Molecular Glues 1/ GlueMap is an advanced computational toolkit designed to optimize the discovery and design of molecular glues (MGs), leveraging structural modeling, molecular

When people started to talk about bitcoins, I read the Satoshi Nakamoto whitepaper to understand how proof-of-work works. Having collected that knowledge and no bitcoin, I felt much enriched. bitcoin.org/bitcoin.pdf If this is a joke, it is on me.

Why this new wave of #AI in drug development different from before? It’s not just about moving faster — it’s about using AI/ML to develop drugs that are inaccessible to older technologies, or address unmet needs in new ways. Thanks Mark DePristo Thomas Clozel Huafeng Xu

No computer game can match the thrill, mental focus, and purpose of structure-based drug design turbocharged with molecular simulations. But you have to wait for a couple of weeks before getting your game score.

The watchful eyes on the wall.

Wenfeng Liang, who founded and led the DeepSeek team, is one of the over one hundred authors of the DeepSeek paper, but he is neither the first nor the last author, and there is no asterisk next to his name. That alone is a distinction.

AI’s results feel adequate when I have no clear expectations—but often fall short when I do.

I share my thoughts on the enabling elements that drive rapid technological advances: public attention, scientific foundation, talent pool and empowering infrastructure, focus on value creation, technology integration, and sufficient investment. tinyurl.com/5n8srpsc

“With due respect” is invariably followed by words spoken without respect.

Is this what people call a dream job?

I like a watermelon because “you can eat, drink, and wash your face all at the same time.” What is this monstrosity that takes away two thirds of the fun?

The most notable effect of AI on science will not be the solution of outstanding scientific problems but the shortening of author list in scientific publications. We might soon see single author papers describing complex scientific works that previously call for a team.

Suspicious?

Did the pants-to-shirts sales ratio decrease with the rise of remote meetings?

I just got recommended to the recruiter for a job I am hiring for. Flattered, twice.

The discovery of a new medicine is a rare event. Can AI help turn the improbable into the likely? My (digressive) thoughts on how AI may impact drug discovery in a meandering post. Title inspired by Blade Runner. Style warped by sleep deprivation. medium.com/@huafeng/do-ne…