Grateful to have been included in this incredible project, alongside such an amazing team!

The ovary might be the most remarkable example of tissue organization in the human body - dynamically remodeling itself hundreds of times across reproductive life. Let's learn how it's organized and how aging disrupts this orchestra. Megathread!🦣🧵

Promoting healthy aging in women. Prolonging ovarian life. Slowing the onset of menopause. A feature @nature nature.com/articles/d4158… open-access And this week's editorial nature.com/articles/d4158…

Modern GWAS can identify 1000s of hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm excited to present our new work combining associations + Perturb-seq to build interpretable causal graphs! A🧵

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis

Today in nature we share our back-to-back stories with Ning Zheng revealing chemical-genetic convergence between a molecular glue & E3 ligase cancer mutations. 1/6

⚡️Really thrilled that #textgrad is published in @nature today!⚡️ We present a general method for genAI to self-improve via our new *calculus of text*. We show how this optimizes agents🤖, molecules🧬, code🖥️, treatments💊, non-differentiable systems🤯 + more!

Our new #preprint on NK cell engineering is out! biorxiv.org/content/10.110… Using #CRISPR activation screens, we found a programmable mechanism to mobilize NK cells to breast cancer tumors by engineering these cells to express orphan and metabolite-sensing receptors. (1/11) The

"Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet" Our study highlighted in nature News nature.com/articles/d4158…

Bio foundation models are great design and engg tools. But can they help decode the fundamental principles of life? We harnessed a single-cell FM for decoding the long-debated relationship between genome arch. and gene coregulation. It all started with an idle curiosity. 1/

What do you do when grants are cancelled, faculty searches are frozen, and the ability to do the science you believe in is slipping out of reach? I wrote an essay. On efforts to solve aging with reprogramming, the primacy of the epigenome, and the path to rewriting our future:

What if LLMs could “read” & “write” biology? 🤔 Introducing C2S‑Scale—a Yale University + Google AI Google DeepMind collab: we scaled LLMs (up to 27 B!) to analyze & generate single‑cell insights by turning transcriptomes into text 🧬➡️📝 🔗 Blog: research.google/blog/teaching-… 🔗 Preprint:

Today on the blog we introduce Cell2Sentence-Scale, which looks deep into how to best represent cells and biological information as text, opening up exciting applications for language-driven single-cell analysis with large language models. Learn more →goo.gle/4jC24dM

Our latest paper on #cardiac #fibrosis is out today in nature. Congrats to Stanford CVI Stanford Medicine researchers led by @Sangkyun_Cho and Siyeon Rhee. And special thanks to computational scientists Greenstone Biosciences for providing #AI #drugdiscovery. Link: nature.com/articles/s4158…

The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts:

Chuffed to share KRONOS: A foundation model for Spatial Proteomics! arxiv.org/abs/2506.03373 Exciting work with the indomitable Faisal Mahmood, led by the amazing Muhammad Shaban, Yuzhou Chang, with Huaying, YaoYu Yeo, Guillaume Jaume, Andrew Song, and our collaborators

Save the Date: The 2nd Yale Center for Research on Aging (Y-Age) Symposium is set for Monday, October 13 at the Anlyan Center at Yale School of Medicine. Join us for a day-long discussion on human longevity, geroscience, and the biology of #aging. @YalePathology. bit.ly/470j7D9

Excited to share that we've received an NIH R35 MIRA! This grant will support our work building tools to study how cell states change over space and time in disease. Grateful to our community, and especially the wonderful team I get to work with.