🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

📰 New study reveals how Hel2-dependent ubiquitin chains mark stalled disomes in yeast, with Ubp2/Ubp3-mediated deubiquitination ensuring ribosome recycling after translational run-off. #RibosomeQualityControl 🔗 doi.org/10.1038/s42003…

Online Now: Structural basis for OAS2 regulation and its antiviral function dlvr.it/TKxlBK

RareFold predicts and designs proteins with noncanonical AAs. With EvoBindRare, we designed linear & cyclic peptide binders with high affinity & novel binding modes, validated in wet lab. A step toward next-gen therapeutics. 📄 biorxiv.org/content/10.110… 💻 github.com/patrickbryant1…

Promoting ribosomal incorporation of backbone-modifying nonproteinogenic amino acids into nascent peptides by ATP-binding cassette family-F proteins and EF-P academic.oup.com/nar/article/53…

🫴 c-di-AMP is synthesized in eukaryotes: The second messenger activates the NLRP3 inflammasome! nature.com/articles/s4158… nature.com/articles/s4158… #cdiAMP Nature Chemical Biology

Our latest story is now online nature! We discovered a phage defense system that deploys kilobase-long DNA homopolymers to protect against viral infection. Congratulations to all authors, and to the Wiedenheft Lab for a fun and fruitful collaboration! nature.com/articles/s4158…

There’s a lot of improvement we can engineer into phages! Phil Huss (UW–Madison) et al published a paper on engineering #phages using metagenomic data showing how deep mining of metagenomic motifs can be used to engineer novel phages w/ desired properties buff.ly/ZZPogPp

Our latest preprint is online! Local translation atlas across organelles is revealed!

A report - with pictures! - from our Fundamentals of Basic and Applied Phage Biology – 2025  Doctoral Program in Infections and Antimicrobials course! ndpia.se/fundamentals-o…

New pre-print(s) from the Sternberg Lab in collaboration with Leifu Chang! We uncover an unprecedented molecular mechanism of CRISPR-Cas12f-like proteins, which drive RNA-guided transcription independently of canonical promoter motifs. Full story here: tinyurl.com/mr3fd493

Excited for New Approaches and Concepts in Microbiology 2025 (#EESMicrobiology) with sessions on Bacterial systems biology, Bacterial cell biology & protein machines, Microbiomes, Environment & evolution, Pathogenesis & phage, Antibiotic discovery, mechanisms, and resistance.

Very cool!

“A transposon-like strategy for proteins” - A News & Views by Barbara Di Ventura highlights recent work Science Magazine on using transposition, normally considered a DNA-based process, for protein semisynthesis and site-specific modification nature.com/articles/s4158…

Time-resolved cryo-electron microscopy can resolve protein motion on millisecond or even microsecond timescales, but the need for highly specialized tools and skills limits the method’s reach nature.com/articles/d4158…

Our Molecular Cell Spotlight on the Hailong anti-phage system from the Kranzusch lab! This defense uses "ssDNA tripwires" to trigger toxic ion channels 🧬⚡☠️ Fun write with Johannes Kühn!!

🎉 Join us in Ghent for back-to-back meetings this Sept! 🔬 Phage Protein Meeting (Sept 10–11): Bigger venue, seats still open! Keynote: Prof. Lone Brøndsted + global experts. 🔗 Program: 🎉 phageproteinmeeting.bionetic.org/program.html

biorxiv.org/content/10.110… New type IX toxin/antitoxin system, anti-phage system Clover, where antitoxin produces 5′-triphosphothymidyl-3′5′-thymidine to inhibit the dGTPase toxin.

Phage counter-defense repertoires: New work IDs broad & specific anti-defense genes in variable regions of Pseudomonas phage genomes. Inhibitors neutralize diverse bacterial immune systems, highlighting how phages evolve broad & specific strategies cell.com/cell-host-micr…

very cool!

A new encyclopedic review, for plasmid lovers: academic.oup.com/nar/article/53… We (Mapi, Eduardo and I) hope you like it!