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Excited to share the latest from the @MarsonLab! An investigation of context-specific gene regulation in T cells, which led to dynamic mechanisms required to control T cell rest and activation. Published today in nature thanks to the work of many! nature.com/articles/s4158…

Excited to share the final chapter my PhD research on medRxiv! eQTLs only explain 30% of GWAS loci and 11% of trait heritability. Here we investigate if epigenetic QTL can provide new insights at the remaining GWAS loci. medrxiv.org/content/10.110…

i don't capitalize anything bc im against capitalism

Excited to share our pre-print "The multi-scale complexity of human genetic variation beyond continental groups" biorxiv.org/cgi/content/sh… Global Genomic Network Communities browser: sohail-lab.shinyapps.io/GG-NC/ Github: github.com/mariajpalma/GG… See🧵thread by lead author María J. Palma

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)? Latest from us. Published today. News here cuimc.columbia.edu/news/what-happ… article here: nature.com/articles/s4158… O'Jay Stewart BogunovicLab and a huge international team thank you 🙏🏼 Columbia Children's Health Lipschultz Precision Immunology Institute

Excited to share my PhD work with BogunovicLab in nature! We highlight the importance of monoallelic expression on the penetrance of genetic disease. nature.com/articles/s4158… Columbia Children's Health Lipschultz Precision Immunology Institute SinaiMSTP Icahn School of Medicine at Mount Sinai #InThoseGenes

Excited to kick off 2025 with our latest publication! We've developed TGFM, a new statistical method for identifying the causal tissue and gene underlying GWAS disease loci—providing new insights into the biology behind GWAS signals. nature.com/articles/s4158…

Thrilled to share our publication Nature Immunology led by the incredible Nargis Khan Kim A. Tran and amazing collaborators Soehnlein Lab Luis B Barreiro bryan yipp @KhaderShabaana fascinating how a fragment of fungi can mitigate lung pathology to influenza rdcu.be/d5AEw

Human embryo editing against disease is unsafe and unproven despite rosy predictions nature Shai Carmi Hank Greely Kevin Mitchell nature.com/articles/d4158… Heritable polygenic editing: the next frontier in genomic medicine? Julian Savulescu nature.com/articles/s4158…

#WeekendRead! #MysterySolved! Why the same mutation can be pathogenic or not? @bogunovicLab @stewart_otay &co show nature that epigenetic controls the random expression of 1 allele in 5% of all genes, explaining incomplete penetrance of monogenic diseases nature.com/articles/s4158…

need Luann at a Traitors roundtable

8th NYC Inborn Errors of Immunity symposium just concluded. 29 outstanding talks! Genetics, AI, Fundamental and Clinical Immunology, Bioinformatics, Animal models. Fantastic attendance. Thank you joshua milner for co-hosting. Columbia Children's Health

My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. It’s available on Amazon: tinyurl.com/mx2hewen

absolutely devastating — i feel incredibly grateful to have had you as a coach and you will be missed dearly, Sasha 🤍

for Sasha & his family gofundme.com/f/remembering-…

We are excited to host Professor Luis Barreiro (Luis B Barreiro) from The University of Chicago for two talks this week! Come learn about the evolution of the human immune system!

Why do some COVID-19 patients fare worse than others? Sacha Morin’s team used AI to study 300 hospitalized patients and understand how specific markers related to their immune response and the infection affected the clinical outcome. Read his blog post: mila.quebec/en/article/exp…

Pourquoi certains patients atteints de la COVID-19 s’en sortent-ils moins bien que d’autres? L’équipe de Sacha Morin a utilisé l’IA pour étudier 300 patient·e·s hospitalisé·e·s et comprendre comment certains marqueurs spécifiques liés à leur réponse immunitaire et à l’infection