New version of LukProt - a protein sequence db focused on early branching animals! With many more species, a preprint: biorxiv.org/content/10.110… And a BLAST server anyone can use: lukprot.hirszfeld.pl Download here: zenodo.org/records/7089120 #evolution

The GlycoWeb BBSRC sLOLA is recruiting! Please circulate to your networks and get in touch for more information. Proteoglycans GRC 2022 Glycobiology.UK Extracellular Matrix News SFGlycobiology Glyco@Alps

We are thrilled to present a new family of microbial mucinases that specifically recognize mucin O-glycan clusters and employ two glutamic acid residues for catalytic cleavage. nature.com/articles/s4192…

A reminder, we are currently searching for a #PhD and #postdoc to join us at the Center for Chromosome Stability in Copenhagen. The positions are fully funded. The deadline for the postdoc position is this Sunday (10.03.24). Details below:

Fushinobu, S. Taking a walk to find new mucinases. Nat Catal 7, 345–346 (2024). doi.org/10.1038/s41929…

Characterization of a cool mucinase subtype bearing features of both glycosidases and proteases ⁦Nature Catalysis⁩ #glycotime A family of di-glutamate mucin-degrading enzymes that bridges glycan hydrolases and peptidases | Nature Catalysis nature.com/articles/s4192…

Paper here: biorxiv.org/content/10.110… . Interesting stuff for the glyco-heads out there. 6-sulfated galactose polysaccharide induces this change somehow. Would be cool if someone could see if rosetteless (or another one of the choano lectins) binds the polysaccharide directly.

Take a look at our new article! Great collaboration with Janneke Elzinga Copenhagen Center for Glycomics on elucidating mucin binding of Akkermansia link.springer.com/10.1038/s41467…

Interesting result tucked away in here that comparing a boutique protein language model (fewer seqs) to the big beasts like ESM-2 or ProtT5, scale wins out again.

academic.oup.com/glycob/article… Great stuff from the Aebi lab as usual!

📈 One standard graph in all bio deep learning papers should be: max similarity to anything in training set vs performance. (Reviewers shouldn't have to guess if there might be overfitting issues).

New review on the proteolytic cleavage of #Golgi enzymes and its impact on cellular glycosylation #glycotime #Golgi #SPPL3 doi.org/10.1016/j.bbag…

Look, I know I am in the medical faculty and all that, but I love this kind of paper SO MUCH. There’s so much here for me to dig into. Mucins(ish), Galectins and LEGO bricks, you couldn’t concoct a better nerd snipe for me.

I’m excited to announce the launch of our company KPL ApS , and website: kplbio.com.  The goal is to make some cool proteins, starting with proteases for #proteomics purposes ☺️. First product is the infamous LysC (lys.bio) but stay tuned more!