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We created an integrated map of scRNA-seq data from 65 non-diabetic, Aab+, T1D and T2D pancreatic islets as a community resource. A thread describing the publicly available tools we generated, all available at isletgenomics.org Kyle Gaulton 🧵... 1/n biorxiv.org/content/10.110…

Tomorrow(06/23) Hannah Mummey from Kyle Gaulton lab will present her work on Mapping Cis-Regulatory Programs Affecting Type 1 Diabetes Risk in Pancreatic Islet Cell Types Using Single Cell Multimodal Profiling. Location: Ballroom 6DE Time: 5:30pm Common Metabolic Diseases Knowledge Portal #ADA2023 #T1D

Our new paper describing genetic association and improved fine-mapping of T1D, and a new model to predict T1D from genetics that also reveals novel interactions and disease heterogeneity Carolyn McGrail Hannah Carter medrxiv.org/content/10.110…

I'm super excited to share this recent preprint from Weston Elison and I 🎉🎉🎉 We characterize how variation in both phenotype and genotype impact gene regulation in pancreatic islets, and then use these findings to predict non-coding diabetes risk mechanisms!