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A must-read! The #DepMap portal is used extensively by the research community to assess gene functions in #cancer, nominate potential therapeutic targets, and identify biomarkers of response. Read in Nature Reviews Cancer on the present and future of DepMap. nature.com/articles/s4156…

Can't wait!!!

Orgchem or biochem folks! How do you manage an enzyme-catalyzed synthesis when your starting material crashes out upon mixing with your protein? It works well on a small scale, but scaling up becomes tricky. Any tips or tricks?

Join us for the final TPD webinar of 2024 on 12/19. @FleurMFerguson & Eric Wang - "ZBTB11 Degraders Target Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC" Slava Ziegler - "Targeting IDO1 by monovalent degraders exploiting the native IDO1 degradation mechanism"

Mind-blowing masterpiece by Brian Liau ZhengLab

Very excited for our next seminar next week! Yuh Min Chook(Yuh Min Chook) at UTSW will share an intriguing allosteric mechanism of drug-induced XPO1 degradation, mediated by the CRL5-ASB8 E3 ligase complex. Join us at 12 pm EST (Feb 20th). Preprint - biorxiv.org/content/10.110…

Couldn’t recommend more highly!! Mikołaj Słabicki is a great scientist and mentor, as well as one of the niceaset friends I’ve ever met👍

A small but meaningful milestone - our lab's first NIH grant NOA! Grateful for the support and excited to get to work! We're hiring! Candidates with experience in biochemistry, assay development, and structural biology are encouraged to apply!

Excited to share my graduate work from the E. John Wherry lab on the molecular mechanisms locking in the differentiation fate of exhausted CD8 T cells (Tex), published earlier this month in @SciImmuno. Main findings below! science.org/doi/10.1126/sc…

A powerful and personal editorial from Nobel laureate Ardem Patapoutian: "I owe America my success. Today, its scientific future is in danger." Please read and share. cnn.com/2025/04/09/hea…

#AACR25 Meetings Highlights session: Thanks to Cory Abate-Shen for summarizing the "fearless chemistry" including degraders and glues to drive new drug discovery efforts. Great coverage of the field also by Ingo Hartung and others, much appreciated 👋 See you all at #AACR26

📢 Save the Date! The next FREE Dana-Farber TPD In-Person Event is coming soon! Join us for an afternoon of cutting-edge science, networking, and community building focused on Targeted Protein Degradation (TPD). Stay tuned for registration and speaker details.