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Impact of TREM2R47H Variant on Tau Pathology-Induced Gliosis and Neurodegeneration pubmed.ncbi.nlm.nih.gov/32544086/ New paper from our lab on effects of TREM2R47H in a tauopathy model. Unlike in amyloid models, it is neuroprotective.

Nice new paper from Monica Xiong in the lab on the interesting potential advantages of a specific type of apoE antibody to target plaques and CAA....pubmed.ncbi.nlm.nih.gov/33597265/

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia cell.com/neuron/fulltex… Congrats to Chao Wang and all our colleagues showing a key role for astroctye-derived apoE4 in degeneration

Nice work by Maud Gratuze regarding the need for reactive microglia to limit Aβ induced tau seeding/spreading. Activated microglia mitigate Aβ-associated tau seeding and spreading | Journal of Experimental Medicine | Rockefeller University Press rupress.org/jem/article/21…

Congrats to Yang Shi and colleagues showing strong protective effects of overexpressing LDLR in brain to tau-linked injury. Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms cell.com/neuron/fulltex…

Congrats to Celeste Karch Celeste Karch on the Rainwater prize!

Great to be able to have a lab holiday party again!

We are now ranked No. 1 in NIH funding among all Neurology departments! Congratulations and thank you to all of our faculty, staff and research participants who made this ranking possible.

Congrats to Tom Mahan, Chao Wang and colleagues showing the effect of astrocyte ApoE3 and E4 removal on amyloid and other phenotypes. …arneurodegeneration.biomedcentral.com/articles/10.11…

APOE antibody inhibits Aβ‐associated tau seeding and spreading in a mouse model onlinelibrary.wiley.com/doi/10.1002/an… New data from Maud Gratuze and Hong Jiang of the effect of targeting apoE in plaques to strongly inhibit Abeta induced tau seeding/spreading

Interesting and surprising results from Nimansha Jain, WashU MSTP, on TREM activating antibody increasing Abeta induced tau seeding and spreading. Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading rupress.org/jem/article-ab…

Great work by Maud Gratuze and collaborators showing the importance of APOE4 and TREM2 in microglial lipid accumulation and gene expression in tauopathy. TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4 cell.com/neuron/fulltex…

ApoE isoform– and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy science.org/doi/10.1126/sc… A delayed tweet. Congrats to Dong-oh Seo and all our great collaborators in this interesting and comprehensive work.

Congrats to Xiaoying Chen and all our wonderful collaborators on this important set of findings. nature.com/articles/s4158…

Congrats to Samira on this beautiful work. science.org/doi/10.1126/sc…

Congrats to Wade Self on an up to date review. nature.com/articles/s4159…

Congrats to Yun Chen and all our co-authors on this important set of findings. Chen Y et al. APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread. Cell. 2023 Dec 6:S0092-8674(23)01315-6. doi: 10.1016/j.cell.2023.11.029. PMID: 38086389.