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Understanding how effector regulatory T cells are controlled by metabolic signaling may help develop treatments for autoimmune disease and cancer. ow.ly/P1EB50Cn5h8 Cell Metabolism Hongbo Chi

New Article now online: In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions zpr.io/RGNgv

Now online! In vivo #CRISPR screening reveals #nutrient signaling processes underpinning CD8+ #Tcell fate decisions bit.ly/2O3nC9v

Diet may play a greater role in immune function than previously believed. Find out more in the Cell paper. ow.ly/VnVj50DJWV2 Hongbo Chi hongling huang

Read about the pathway tumors use to harness regulatory T cells for their own protection. Then checkout what happens when the newly identified pathway is blocked. ow.ly/XYFP50DIRI5 @nature Hongbo Chi

Preview In this issue of Cell: How to make a better T cell: in vivo CRISPR screens have some answers,How to make a better T cell: in vivo CRISPR screens have some answers zpr.io/R7G4T

PTEN is often mutated in human cancer, but its normal function has remained mysterious. St. Jude immunologists showed PTEN prevents T-cell cancer and autoimmunity. Explore the mechanism in Nature Cell Biology. go.nature.com/3FnrPxq Daniel Bastardo Blanco, PhD Hongbo Chi #immunology

go.nature.com/3Wg5zMi

nature.com/articles/s4155…

NEW Review: CRISPR screens for functional interrogation of immunity bit.ly/3hdISIQ by Hao Shi, Hongbo Chi & @JohnDoench discusses recent applications of CRISPR screening of immune cells in infection, inflammation and cancer

Hao Shi, @Hongbo_chi, and @JohnDoench review progress in an emerging adaptation of #CRISPR technologies to advance our fundamental immunological knowledge, and identify novel disease targets for #immunotherapy. 🎯 Check it out in Nature Rev Immunol: 📚 go.nature.com/3YvDHoi

Early immune pressure makes tumors metabolically stronger dlvr.it/SgTq7h

Scientists at St. Jude found immune and tumor cells compete over glutamine with significant implications for anti-cancer activity. The findings show that supplying glutamine directly to tumors helps initiate the immune system’s cancer-killing activity. bit.ly/44ynMaY

Read Cancer Discovery's #ResearchWatch: Glutamine Influences Type-1 Conventional #DendriticCell Antitumor #Immunity, a summary of the paper by Chuansheng Guo, Hongbo Chi et al. bit.ly/3DprWGP St. Jude Research

Excited to share our latest studies published in Nature yesterday “Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer”nature St. Jude Research nature.com/articles/s4158…

Online now! #Review Metabolic rewiring and communication in cancer immunity by Nicole M. Chapman and Hongbo Chi at St. Jude St. Jude Research dlvr.it/T3bxcs #chembiol

Featured content from our new anniversary focus issue on #Immunology: "Principles and therapeutic applications of adaptive immunity" Read the review: cell.com/cell/fulltext/… Hongbo Chi Paul G Thomas St. Jude, Marion Pepper University of Washington #50YearsofCell

This review by Raynor & Hongbo Chi highlights the signaling and functional effects of nutrients as Signal 4 in T cell–mediated immunity. hubs.la/Q02vxQNH0 From our #Immunology collection: hubs.la/Q02vy4y_0 #AAI2024