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✨Online today Nature Genetics from Andrew Bassett Jeremy Schwartzentruber and colleagues: Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer’s disease risk genes🧠🧬| go.nature.com/3u1G432

Stratifying trans-ethnic genetic correlations reveals that loci with population-specific disease effect sizes are likely impacted by selection Huwenbo Shi (時胡文博) @StevenGazi Masahiro Kanai @samsungilkim Yang Luo Tiffany Amariuta YukinoriOkada Soumya Raychaudhuri সৌম্য রায়চৌধুরী Harvard PGSG nature.com/articles/s4146…

Come join us (virtually, obvs) for the Personal Genomics conference on 28-30 April! Fantastic speakers include Amit V. Khera Eimear Kenny Anna Middleton Edward Dove Michael Snyder, PhD. Abstract submission deadline is 2 March. Register now! 🧬😊🧬😊🧬😊🧬#PersGen21 …dconferences.wellcomegenomecampus.org/our-events/per…

So, your LDL is >190. Well, your risk of suffering a heart attack is powerfully dependent on your polygenic background (even after accounting for all other risk factors) P.S. what Amit V. Khera and I have been saying for several years ahajournals.org/doi/abs/10.116…

📣Data Release Alert📣 On our 220 cross-pop deep-phenotype GWAS project, I have compiled all 220*3 GWAS summary statistics, and Super Masahiro Kanai deployed them into the beautiful web portal!! You can search and download everything at pheweb.jp 🧵

Our lab is expanding! We seek outstanding comp scientists to join our multidisciplinary team (kheralab.org/team) working at the interface of genetics, ML, and clinical medicine. Please RT! Apply today or DM with ?’s: bit.ly/2StK12l bit.ly/33khsWV

Yes, Virginia, summary statistics from many cancer genome-wide association studies are publicly available! #sumstats #cancer #gwas docs.google.com/document/d/13j…

Association between adiposity and cardiovascular outcomes: an umbrella review and meta-analysis of observational and Mendelian randomization studies. Discover more in EHJ! ow.ly/SxXY50FHUSS #CVD #CAD #stroke #adiposity #metaanalysis #cardiotwitter European Society of Cardiology European Society of Cardiology Journals

Happy to share our work just published in European Heart Journal EHJ Editor-in-Chief. Great work by Min Seo Kim, MD, MSDH , Amit V. Khera et al.

Ko et al. identify 30 new genetic markers for occupational attainment, and show that high levels of occupational attainment are associated with reduced risk for Alzheimer’s disease, even after taking educational attainment into account. bit.ly/3p3ZlRl

Won et al. compare genetic associations with subjective wellbeing (SWB) in Korean and European populations, and show significant cross-population genetic correlations. Hong-Hee Won buff.ly/3yGWUci

A polygenic risk score (PRS) derived from a European GWAS identified those at high risk for Alzheimer dementia in Korea, emphasizing the transferability of PRSs and suggesting the importance of enriching diversity in genetic studies of Alzheimer disease. ja.ma/3j4tkrm

I often post how studying the effects of genetic variation on gene expression can reveal disease mechanisms & novel drug targets🧬-->💊 Our paper at AJHG links disease GWASs with single-cell gene expression to uncover cell-specific drivers of atherosclerosis👇[1/9]

Nice systematic analysis of gene convergence between common and rare variant GWAS discoveries. Not often we see common and rare variant studies implicating the same set of genes for a trait. This convergence is rare particularly for traits under strong selection like early

Delighted to share the preprint on the largest obesity GWAS to date! GWAS from >2 million participants Key: ✳️13% increase in loci discovery ✳️Identified 11 obesity genetic clusters (endotypes) ✳️Obesity management should be as diverse as the condition itself Thread👇

New preprint from our group advancing genetic discovery and biologic understanding of obesity - Multi-trait GWAS of >2 million people - Discovered 743 loci including 86 novel - Defined 11 distinct obesity endotypes driven by metabolic resilience, insulin physiology, beta

Happiness is highly linked to how focused you are on what you're doing. A wandering mind is an unhappy mind.

My new weekly read list with 5 interesting papers from the fields of genetics, omics & deep phenotyping 🧵 1⃣snRNAseq provides proof for adult human hippocampal neurogenesis 2⃣A multitrait GWAS of adult obesity 3⃣A review of FDA-approved AI medical tools 4⃣A new deep

Chocolate consumption enhances cognitive function. There is powerful correlation between chocolate intake & the number of Nobel Prize recipients.