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Major update to NextBrain segmentation! Version 1 was unusable without a huge GPU. New release: 1. Uses Rohit's FireANTs & simplified atlas to segment a brain in 20-30 mins without a GPU (or minutes on a GPU). 2. It is more robust. Give it a try! surfer.nmr.mgh.harvard.edu/fswiki/HistoAt…

NeuroImage: État Criblé—High-Resolution MRI and Metabolism hubs.la/Q034TwgQ0 #NeuroTwitter #NeuroX

TSPO PET is used to measure inflammation in dementia, but its cellular basis is unclear. Using PET imaging and post-mortem brain tissue, Wijesinghe et al. show that microglia are the key immune cells driving TSPO PET signal changes. tinyurl.com/mwpxdcc6

The "Chocolate Chip Sign" on susceptibility-weighted imaging (SWI) represents a novel and promising neuroimaging biomarker for HTRA1-related cerebral small vessel disease. Read this study to learn more: hubs.la/Q038vwm70 #NeuroGenetics #NeuroX

⚡️🩸🧠 Practical framework for diagnosing Cerebral Amyloid Angiopathy-related inflammation (CAA-ri) We frequently discuss challenging CAA-ri cases with colleagues around the world. This framework summarizes key diagnostic features across the CAA-ri spectrum in a clinically

I am excited to present our new study out in Nature Medicine where we discover a novel synaptic protein biomarker to predict if and when someone will get Alzheimer’s disease dementia. Part 2/3 from my PhD work in the Tony Wyss-Coray lab. 🧵1/12 Full study 🔗: nature.com/articles/s4159…

TSPO PET is used to measure inflammation in dementia, but its cellular basis is unclear. Using PET imaging and post-mortem brain tissue, Wijesinghe et al. show that microglia are the key immune cells driving TSPO PET signal changes. tinyurl.com/mwpxdcc6

The "Chocolate Chip Sign" on susceptibility-weighted imaging (SWI) represents a novel and promising neuroimaging biomarker for HTRA1-related cerebral small vessel disease. Read this study to learn more: hubs.la/Q03f_g3r0 #NeuroGenetics #NeuroX

Blood biomarkers of vascular dysfunction in small vessel disease progression: Insights from a longitudinal neuroimaging study - Jaime Garcia - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Alzheimer disease biomarkers are present in various dementia types, with the strongest correlations between cerebrospinal fluid biomarkers and cognitive function seen in patients with early and late onset Alzheimer disease. ja.ma/4jFRZNa

🧠 Check out our new paper in Alzheimer's & Dementia Journals exploring how tau depletion improves vascular amyloid‐related deficits in a mouse model of CAA Thanks to Alzheimer's Association The Rainwater Charitable Foundation NIH Funding for supporting this work! alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Individuals with more severe clinical Alzheimer disease symptoms than their biological stage often have additional pathologies. ja.ma/3H0b6TU

Using multi-modal imaging, Kozberg et al. report that loss of vasomotion occurs early in cerebral amyloid angiopathy in a mouse model. This loss coincided with initial vascular amyloid-β deposition and preceded the occurrence of microbleeds. Read at buff.ly/duW26H0

A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting nature.com/articles/s4159…

Donahue et al. review the anatomy and function of the parasagittal dural space, highlighting its roles in neurofluid egress, neuroimmune surveillance, and in the clearance of proteins implicated in neurodegenerative disorders. tinyurl.com/mpwbzax4

Cortical Cerebral Microinfarcts in Spontaneous Intracerebral Hemorrhage on 3T and 7T MRI | Neurology neurology.org/doi/10.1212/WN…

Zhang et al. show that in cerebral small vessel disease, the oxygen extraction fraction first increases and then decreases, suggesting an initial compensatory response that gradually fails with disease progression. tinyurl.com/3ckfnmdh

Wang et al. developed a multi-label deep learning framework to identify neuroimaging signatures for AD, vascular dementia, and LBD using antemortem MRI. The model uncovered distinct patterns of alterations associated with each pathology. tinyurl.com/c6mh9vnh

In a new #ScienceReview, researchers provide a critical evaluation of research linking glymphatic dysfunction with Alzheimer’s disease. scim.ag/44Hh18I

Using a mouse model of Parkinson’s disease, Lopes et al. show that dysregulation of aquaporin-4 water channel complexes may impair glymphatic function, contributing to α-synuclein accumulation in the brain. tinyurl.com/exxvhtcm