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Glucocorticoids (GC), like dexamethasone and prednisolone, are widely used in medicine, but how do they actually work? This is really impressive work (Auger et al.), which figured it all out There are two mechanisms: a slow, broad response, which depends on transcriptional

A correlation between increased cardiorespiratory fitness (V02 max) and protection from brain aging (reflected by less demyelination) pnas.org/doi/epub/10.10… PNASNews Mustapha BOUHRARA

Encouraging topline results regarding #tolebrutinib! In Hercules trial, tolebrutinib delayed disability progression vs. placebo in secondary-progressive MS patients without relapses. Thanks to our center's patients that participated in the trials! bit.ly/4g5WHCL

Diagnosing Multiple Sclerosis-NEW MS Living Well Podcast with Drs. Léorah Freeman & Xavier Montalban bit.ly/3XD3Enu🍎apple.co/4glMLVC Get informed of early symptoms & swifter diagnosis S Gnanapavan Hugh Kearney Trishna Bharadia BA(hons), MFPM(hon) روميزا حسين اليافعي Rumaiza Alyafeai Ahmed Z Obeidat, MD, PhD

How are you celebrating this year's Vestibular Disorders #BalanceAwarenessWeek? Dizziness & imbalance are common in people with MS. Delighted to be here ECTRIMS showing our research on prevalence of vestibular symptoms in pwMS & relationship to MRI Hugh Kearney St James's Hospital

Delighted to share our multi site research exploring effect of the Exoband on walking in pwMS with hip flexor weakness #ECTRIMS2024 Eoin Synnott Susan Coote MS Ireland St James's Hospital Hugh Kearney ECTRIMS

Big congrats to Shane O’Carroll and Christian Peace who led this study in our lab- a metabolite called Itaconate already known to be anti- inflammatory also drives anti-viral interferons via blocking the enzyme SDH. Funded by the ERC and Research Ireland tcd.ie/news_events/ar…

Congratulations to Martina McKenna cANP MS, our winner in the Osteoporosis quiz to celebrate World Osteoporosis day 20/10/2024. #Saynotofragilebones Niamh Maher Claire Rosie.Lan Care of the Older Person, Education & Training Sharon Slattery DoN St James's Hospital FLS Database Ireland #avonmoremilk #accordhealthcare

JCI - Accumulation of Epstein-Barr virus–induced cross-reactive immune responses is associated with multiple sclerosis jci.org/articles/view/…

Importance of this model nicely contextualized in this commentary Next up: "The ability to predict the effects of mutations across all layers of regulation in the cell and to design DNA sequences to manipulate cell function would have tremendous diagnostic and therapeutic

Brian Hie and I also have a joint postdoc position open (for ML and synthetic biology projects), as well as roles in our Technology Centers. Several posted (and unposted jobs!), check out arcinstitute.org/jobs to learn more or just contact us anyway

We mourn the loss of Prof. Giancarlo Comi, a pioneering neurologist in multiple sclerosis research. As a former ECTRIMS council member and European Charcot Foundation (European Charcot Foundation) founder, his contributions have profoundly shaped the field and patient care globally.

Guardians of the Brain. A brief review of 6 recent, important reports that help us understand the brain-immune system axis in the new Ground Truths, open-access (free) Relevance: #LongCovid, brain tumors, multiple sclerosis, ME/CFS, autoimmunity

Dr. McElheron!😱🎊 Elated to announce I passed my PhD viva voce🎉 a hugely emotional day, couldn't have asked for more from my amazing supervisors or my nearest & dearest😭💖 HUGE thanks to Claire Steves, Prof McManus for examining, & to Provost Linda Doyle for the support 🙏

This monster is out today - a large piece of research/writing over 2 years, with great input from our clinical and pharma collaborators - particular congrats to Almudena - funding from Research Ireland 👉 sciencedirect.com/science/articl…

👍😀👩🏼‍⚕️🔬‼️#Tolebrutinib designated Breakthrough Therapy by the FDA for non-relapsing secondary progressive multiple sclerosis. This will potentially expedite approval and availability! sanofi.com/en/media-room/…

New RCSI School of Pharmacy and Biomolecular Sciences research explains how our body clock influences the inflammatory process of the immune system. The findings could pave the way for time-targeted treatments for inflammatory diseases like arthritis. ➡️ rcsi.com/dublin/news-an… #RCSIdiscover Annie Curtis - Clock Lab RCSI

Living with MS? Share your views on cannabis-based medicines in a quick, anonymous survey led by Dr. Eric Downer at Trinity College Dublin (TCD). More info here: ms-society.ie/research/lates… Eric Downer Trinity College Dublin

A vaccine could - in theory - prevent EBV-related autoimmunity, in addition to preventing the cancers that are caused by EBV There are no vaccines approved yet, but early trials are ongoing nature.com/articles/s4159…

Evidence that another immune mediated disease - primary sclerosing cholangitis (PSC) - associated with Epstein Barr Virus tinyurl.com/5n8f6jvy