beauty of neuroscience. I can sit in front my computer watching these images for hours.

neurons in spinal cord, brain and the paw of adult mice. Imaged with a 40/1.3 NA Leica Sp8 confocal. Processed with TESOS method.

A Starship? This is a Drosophila's head. One of my students did this imaging for learning our TESOS method. Red: nuclear RFP. Blue: autofluorescence. 40X/1.3 confocal objective. I'm seriously considering imaging a whole fly. Just for fun!

New February issue 📢 This cover features an insightful cartoon showing a neuron network and nonneuronal cells. TESOS, a new tissue clearing pipeline, is also introduced for imaging sensory neurons. Read pages 124–139 for more details by Yating Yi et al. nature.com/cr/volumes/34/…

Our TESOS (Transparent Embedding Solvent System) method paper is finally online. nature.com/cr/volumes/34/… A fundamental challenge for all tissue clearing methods is the inevitable loss of resolution and signal quality in the deep tissue regions. TESOS was specifically designed to

A collaboration with my neighboring lab is on Biorxiv. biorxiv.org/content/10.110… Dr. Jianglai Wu designed a curved light sheet microscope for high-speed, large-volume imaging. He imaged an entire intact cleared mouse brain at a voxel size of 0.625 × 0.625 × 1.25 μm3 within just 3

Invited by LiT Inc., I will be giving a Zoom meeting on May 29th EST to introduce the PEGASOS and TESOS methods developed in my lab. I will also present some unpublished results on high-speed mesoscale projectome mapping of mouse brains. By the way, I will actually be physically

Great morning at the China Institute for Brain Research! Thanks to Hu Zhao for organizing!! This is me with Rui Lin, Minmin Luo, Hu, and Shilin Zhong in front of some beautiful brain images.