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Now published in BMC Medicine! bmcmedicine.biomedcentral.com/articles/10.11… Thanks again to Tom Richardson Neil Murphy Emma Vincent Joshua Bell Eleanor Sanderson @NeliMUlrich Nicholas Timpson george davey smith IARC ICEP MRC IEU WCRF and many others

We have a few exciting paid Summer Internship opportunities in the Genomic Sciences group at GSK! Check out this one on solving human genetics questions in industry and working with the talented Rajashree Mishra: lnkd.in/ef79_hkm #hiring #intern #genetics #GSK

PhD STUDENTSHIP OPPORTUNITY!!! Come and work with us in the sunny south west. Interested in data, genetics, diabetes, pregnancy? Want great support, mentorship and training? Apply *by 31st March*: tinyurl.com/yckreunb NIHR Exeter Biomedical Research Centre (BRC) Inês Barroso Exeter Birth Weight Genetics Group

We have an exciting PhD opportunity available at GSK with colleagues from MRC IEU. Come and develop novel methods to enhance drug development at the interface of industry and academia 😊 (with excellent travel/training awards and generous stipend!)

Age-specific effects of weight-based body size on fracture risk in later life: a lifecourse Mendelian randomisation study dlvr.it/SnTkzw

New paper out with fantastic colleagues Stefan Stender & george davey smith published in the IJE academic.oup.com/ije/advance-ar… 🥳. We evaluated the effects of genetic variants and risk scores on biomarkers for fatty liver disease during the early stages of life using Children of the 90s data

Integrative multiomics analysis highlights immune-cell regulatory mechanisms and shared genetic architecture for 14 immune-associated diseases and cancer outcomes AJHG article ASHG Claire Prince Tom Richardson hubs.li/Q01L6xt60

Applying a lifecourse Mendelian randomization approach to family history data recapitulates evidence of time-varying effects of childhood adiposity on disease endpoints. Many thanks collaborators Helena Urquijo Michael V Holmes (he/him) george davey smith 🍻🥳🙏

Full summary statistics for our UKB-PPP GWAS of 1,463 circulating proteins are now available at synapse.org/#!Synapse:syn5… This includes full cohort (n=52,363), discovery (n=34,557), & African ancestry (n=931) analyses. More subpopulations (AMR, CSA, MID, EAS) available next week.

🤩 Excited to share a pre-print where we find a plausible mediator of the unexplained protective effect that childhood adiposity has on breast cancer risk – mammographic density! Using Mendelian randomization and mediation analysis, we showed that it mediates 56% of the effect.

Join our industry session at #ASHG2023: past, present and future of the application of genetics and genomics to drug discovery and development. Including geneticists in pharma Manolis Dermitzakis, Mark McCarthy Slavé Petrovski Johanna Howson Melissa R Miller

Thrilled to be part of the team making this data available to the UK Biobank research community. Our initial look at the data here and I am looking forwards to all the amazing discoveries this resource will enable. medrxiv.org/content/10.110…

Really pleased to see our paper published in eBioMedicine – The Lancet Discovery Science this week. We found that weight loss in people recently diagnosed with type 2 diabetes altered levels of cancer-related proteins in blood🩸. …w-sciencedirect-com.bris.idm.oclc.org/science/articl…

Exploring the #genomic architecture of circulating #cytokines in the largest to-date dataset of 75,000 individuals, we find 👉169 loci associated with cytokine levels 👉 promising drug targets for immune-mediated diseases Check out for more: medrxiv.org/content/10.110…

Pleased to share that our paper showing that mammographic breast density mediates the protective effect of early-life body size on breast cancer risk is out in Nature Communications! nature.com/articles/s4146… MRC IEU ICEP

Fantastic work Scott 🥳🥳🥳

Our study is now out in molecularpsychiatry using a combination of complementary #causalinference #epidemiological #methods to investigate the role of prepubertal body image dissatisfaction in the relationship between body size and disordered eating & self-harm pubmed.ncbi.nlm.nih.gov/39138355/

Exciting job opportunity to come and work with our brilliant team GSK 😊 Help us improve the healthcare of patients by leveraging large-scale human genetics & 'omics data gsk.wd5.myworkdayjobs.com/GSKCareers/job…

🧬GWAS is fundamental in drug discovery, linking disease to genetic variants. However, studying rare and uncommon diseases with GWAS is hard due to the huge sample sizes required. How can we use AI to help GWAS with small cohorts? In a multi-year collaboration GSK

Our GWAS meta-analysis on the genomic architecture of 40 circulating cytokines in 75,000 individuals is now out Communications Biology 🧬❗️ A short thread about the topline findings🧵