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Iain Cheeseman Ally_Nguyen Whitehead Institute Massachusetts Institute of Technology (MIT) Nice! I❤️science art. Currently, sitting at Heathrow in a shirt with a design by Nat B. Wang 🧬🧑🏻‍🔬🏳️‍🌈 . Students are the most creative!

Come join us at Yale MCDB, a very supportive and inspirational department addressing fundamental open questions in biology!

"Cells have axes of control that they use to quickly make broad changes in gene expression...Our work identifies another axis of control, and we’re excited to discover more about when and how cells make use of it," Iain Cheeseman says. wi.mit.edu/news/elegant-s…

🧫 Dr. Iain Cheeseman and his lab at the Whitehead Institute and Massachusetts Institute of Technology (MIT) have identified how cells switch to a different pattern of protein variant production using #eIF1 during #mitosis. 📰 Press release: bit.ly/3NVbZgQ 🔗 Abstract in nature: go.nature.com/3NRqxOu

"For a long time, people didn’t think much protein production happened in mitosis at all. It was satisfying to show not only that it is occurring, but that there’s a shift in which proteins are being made," graduate student Jimmy Ly says. wi.mit.edu/news/elegant-s…

Su, Radul, Maier, Tsang, Iain Cheeseman et al Whitehead Institute use #CRISPR/Cas9 functional genetic screens to reveal factors affecting cell sensitivity to antimicrotubule drugs, revealing new players in #microtubule function & new roles for established MAPs hubs.la/Q02Z4b_B0

Functional genetics reveals modulators of antimicrotubule drug sensitivity. New study from Kuan-Chung Su, Elena Radul, Nolan Maier, Mary-Jane Tsang, Iain Cheeseman Iain Cheeseman and colleagues Whitehead Institute: hubs.la/Q02Z44f60 #Microtubules #CellDivision #Cytoskeleton

Excited to share that the Nguyen lab website is live Nguyenlab.org ! Check out what we are working on and if you are at ASCB next week come say hello! We will be presenting a poster Monday at board B277

We are excited to kick off the new year with a new publication from the lab!

New preprint w/ surprising insights into proteasomes + mitosis. Océane Marescal found strikingly different cellular phenotypes for proteasome knockouts. 19S lid depletion results in ubiquitin-INDEPENDENT degradation of KIF11 motor + monopolar spindles. biorxiv.org/content/10.110…

New preprint! Eric Smith + Jimmy Ly reveal a beautiful example of repurposing of a molecular machine. RNase P + RNase MRP share 9 subunits and yet are functionally very different. We find key new subunits that act as specificity factors to distinguish MRP. biorxiv.org/content/10.110…

Researchers in the Cheeseman lab have identified an important molecular switch that induces a distinct pattern of protein variant production during mitosis. #ResearchHighlights

New preprint drop! Check out work from Jimmy Ly et al for how protein isoforms generated by alternate translation initiation create dual localization, contribute to mitochondrial function, and are mutated in disease. Tweet-tutorial thread below. biorxiv.org/content/10.110…

Optical Pooled Screening has transformed large-scale cell biology, but lacks robust end-to-end computational strategies to process these Tb-sized datasets. New from Di Bernardo et al (Matteo Di Bernardo): Brieflow. A game changer for OPS + new biological insights biorxiv.org/content/10.110…

Optical pooled screening is revolutionizing functional genomics by linking genetic perturbations to complex cellular phenotypes at unprecedented scale. But analyzing these massive datasets has been a major bottleneck - researchers face fragmented tools, multiple format