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Been doom scrolling. Won't recant dangers. A basic mischaracterization: 50% overhead is 33% of a grant. 100% grant + additional 50%= 150%. 50%/150%=0.333 Twitter and Bsky are basically echo chambers. Flipped images of what this means. Reality is in middle. Hurts USA.

The best study I know estimates that each dollar of NIH spending generates $1.40-$2.80 in value counting *only the private return from drugs*, ignoring consumer surplus, med devices, public health, behavioral science, etc...

Big Data Bayesian Truths: No Vancomycin Trough Concentration Target is Sufficiently Precise for Safety or Efficacy ✅ Just Accepted ✍️ Marc H. Scheetz 🔗 bit.ly/4hMYKvn

Scientists and universities: defend indirects as a concept but not current indirect rates. Don't think there's waste in those numbers? We (US science) spend $4.5 billion on journals. That is HALF of the proposed cuts in indirects, and eliminating that spending would make science

Woof! In the dog camp.

AI is going to start prescribing 😳 schweikert.house.gov/2025/02/05/hea…

It's clear that many do not understand what NIH-funded research does to improve health. It's time to revive a study published 10 years ago that provides incredible information about this. link in the comment Every single new drug approved by the FDA from 2010–2016 was built on

Microsoft will literally invent a new form of matter instead of fixing Teams

🆕️⚡️Pharmacokinetic modeling and simulation study Erin Barreto Marc H. Scheetz BLOOM study group Cystatin C-Guided Dosing Nomogram Improves Target Attainment for Cefepime in the Critically Ill #idxposts Ignacio uman journals.lww.com/ccmjournal/ful…

Thanks DOGE. Clozapine REMS. I had to do this regularly while a resident. Never once did I consider it unnecessary. Agranulocytosis rate that approaches 1%: potentially reversible but can be fatal if missed. Glad we aren't checking any more. Winning. fda.gov/drugs/postmark…

"Why is it that nobody can reproduce anybody else’s findings?": A pharmacologist discusses his upcoming book. cen.acs.org/policy/publish…

Certainly not what I was betting cnn.com/webview/us/liv…

Cosign. idsociety.org/news--publicat… via IDSA

From 70F to snowing. It’s spring in the Midwest!

As I contemplate my life choices (spending countless hours writing proposals) …. Maybe the answer was meme coin. 🤪

One job that I won’t miss AI taking is the contract contract lawyer in research… takes 8 months only to get one or two redlines. So much red tape. Hope AI fixes it so it is not an arm wrestling match where the arm wrestlers get to bill for time spent arm wrestling.

📊💊 How does PK/PD impact clinical outcomes? Join Dr. Marc H. Scheetz at #MADID2025 for \PK/PD Clinical Applications and Outcomes 🔬⚡ Don’t miss these essential insights—register today! 👉 mad-idmembership.vfairs.com 🗓️ Marc H. Scheetz SIDP SHEA ACCP INFD PRN

A wonderful kickoff to the #MAD-ID meeting--- Fellow's forum is a chance for pharmacy fellows to present their novel work. A great and inspirational keynote on obtaining funding from Dr. Courtney Fletcher.