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Human mitochondrial DNA is one of the most simplified cellular genomes that facilitates compartmentalized gene expression.  We wondered what was the (in)fidelity of the process. 1/ science.org/doi/10.1126/sc…

Thanks for the highlight of our study, Rachel Bear and Tamara Caspary (she, her, hers)

Our January cover shows a scanning electron microscopy micrograph of ependymal cells lining the surface of a mouse brain ventricle. From Olesia Ignatenko et al Anu Suomalainen-Wartiovaara Lab (bit.ly/3hKkL4D). Read JCB’s January Issue: bit.ly/3BXac5c

⚡️Just published a review in Trends in Neurosciences about mitochondrial signalling and homeostasis!⚡️ We discuss the cell biology of all things mitochondrial (contacts, vesicles, metabolism, proteostasis, mitophagy...) and their roles in disease. cell.com/trends/neurosc… (1/4)

Offensive that we still need international womens day. But womens rights are eroding in brutal ways across the globe. Progress is routinely greeted with backlash - Iran, USA, Afganastan, and so many abuses worldwide. We must stand together with our allies. bbc.com/news/magazine-…

Preprint alert! Akihiro Yamashita, Olesia Ignatenko and friends studied the consequences of acute loss of peroxisomal LONP2 in cultured lines. Some surprising findings and validation of peroxisomal function in cholesterol flux. We'd love any feedback! biorxiv.org/content/10.110…

For those in Montréal, here’s the first of our new in-person seminar series on mitochondrial biology hosted by ⁦Dr. Jennifer Estall⁩ at ⁦⁦IRCM⁩ . Future meetings at ⁦⁦Centre de recherche du CHUM⁩ ⁦McGill University⁩. ⁦… ⁦Heidi McBride, Ph.D⁩ #jackcollier

Dear colleagues at #KSInnateImmune23 #KSMyeloid23 , do go to ski - the mountains are gorgeous. But also, do use sunscreen…

Looking forward to discuss all things mitochondria in immunity tonight. Poster 1539 'Mitochondrial SUMO E3 ligase MAPL is required for antiviral defence in vivo.' #KSInnateImmune23 #KSMyeloid23

So humbled with recognition from the Brain Research Society of Finland for the ‘best Ph.D. thesis in neuroscience of 2020-2022’ award, and thankful to the support of so many ❤️ It is fun to once again look back, reflect, and visit Helsinki, even if only virtually this time. ✈️

Very happy to share my first paper from the McBride lab Heidi McBride, Ph.D revealing that ­­mitochondrial DNA (mtDNA) can escape into cytosol through “leaky lysosomes” and cause pyroptotic cell death. (1/9) biorxiv.org/content/10.110…

Pre-Print alert* 👋 Follow Jacks Jack Collier fun recap of our newest work. Many thanks to Aligning Science Across Parkinson’s support, the Desjardins team, Olesia Olesia Ignatenko, Sid HuangLabMcGill and twiXless Mai Nguyen! (*data subject to improvement after peer review)

Thank you JCB for selecting our article on metabolic ciliopathy of astrocytes as one of the 10 highlights of 2023 in the journal’s special issue ”Year in Cell Biology” Olesia Ignatenko Gulayse Ince Dunn Medicine and Health, University of Helsinki University of Helsinki STEMM Research Program Anu Suomalainen-Wartiovaara Lab HiLIFE_Helsinki

Sarah O'Keefe and I are recruiting postdocs for an exciting project funded by Business Finland. Come join us at the Institute of Biotechnology Institute of Biotechnology (BI) , HiLIFE HiLIFE_Helsinki , University of Helsinki University of Helsinki . Please retweet/repost. Apply here: nature.com/naturecareers/…

Please check out out our paper with JacksonLab and Brendan Battersby👇 Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation cell.com/iscience/fullt… Geoffray Monteuuis Krysia Broda 🔬 Elizabeth Pyman Diego Balboa 1/7

Would you want to attend a conference where you can only talk about the weaknesses of your own research? Would you be willing to give a talk on that?

#HiringNow: #Postdoc positions open for enthusiasts of pancreas development, #stem cell-derived islets and #diabetes at our new lab University of Helsinki Medicine and Health, University of Helsinki STEMM Research Program . Join our team in Finland 🇫🇮, happiest country in the world! Apply by 15.10.24: jobs.helsinki.fi/job-invite/348…

Starting to explore the other side…😜 Let’s find each other! bsky.app/profile/ignate…