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Is there a bigger scam than the requirement that labs have pay the university "tuition" for graduate students that are working full time in the lab (e.g., year 3 and up)? Why do the NIH and other funding agencies allow this? A pointless drain on research $$$ that makes no sense.

Excited to share our new study published online PLOS Genetics #PLOSGenetics: A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy. dx.plos.org/10.1371/journa… Ben-Gurion University of the Negev Stanford CVI @StanfordCTSurg @yzhang7517 Isaac Perea

Now online Nature Genetics! Our efforts to pinpoint functional noncoding SNPs in AD and PD using scATAC-seq, HiChIP, and an integrative machine learning paradigm. Great collaborative work w/ Anshul Kundaje (anshulkundaje@bluesky) @sbmontgom William J. Greenleaf Howard Chang and Tom Montine nature.com/articles/s4158…

We are excited to share our new multi-omic method, Spear-ATAC, which enables simultaneous read-out of CRISPR sgRNA sequences alongside droplet-based single-cell chromatin accessibility profiles! Great collaboration with Jeffrey Granja, William J. Greenleaf, and 10x Genomics!

The latest version of umap-learn is now out. Version 0.5 includes some major new features, including ParametricUMAP, DensMAP, AlignedUMAP, model composition, and model updating. Thank you to everyone who contributed! 1/14

Base-resolution models of transcription-factor binding reveal soft motif syntax nature.com/articles/s4158… Its ALIVE!! 1/

ArchR is now online at Nature Genetics! A one-stop shop for all of your scATAC-seq data analysis needs. Led by Jeffrey Granja and in collaboration with Howard Chang and William J. Greenleaf. Analyze >1.2M cells on a laptop! nature.com/articles/s4158… ArchRProject.com

OK I found my words. I am howling with rage tonight at the rising tide of violence and hate crimes directed towards Asians in America, punctuated by the horrific shootings yesterday in Georgia at 3 Asian-owned business that claimed 8 lives, including those of 6 Asian women.

Finally --- the 2nd edition of ISLR is out!!!!🥳🎉🪅🍾 Well, sort of. 🙄It's "published", but due to shortages in the global paper supply, hard copies won't be available for a bit longer 😢😭🤦‍♀️ You can pre-order a hard copy from Springer/Amazon, & **download the pdf today**! 1/

#OriginalResearch: The unfolded protein response as a compensatory mechanism and a potential therapeutic target in PLN R14del Cardiomyopathy. Learn more here: ow.ly/mdVH50FKv2K #AHAJournals Ioannis Karakikes Stanford Medicine @StanfordCTSurg Stanford CVI RM Utrecht @CirculatHealth

One of my all-time favourites. Stare at the red dot on the woman's nose for 30 seconds, then look at an empty wall while blinking quickly. Promise it's worth it... bit.ly/2UbzN7W

nature.com/articles/s4156… very glad that our review on Cardiac Enhancers is out. The Foo Lab will be paying close attention to development of enhancer targeted disease therapies. Exciting stuff... Yong Loo Lin School of Medicine NUS CVD Programme A*STAR Genome Institute of Singapore (A*STAR GIS) pic.x.com/sdComiXo16

Proud to finally have our paper on RARG agonists to prevent doxorubicin cardiotoxicity published in Cell Stem Cell. cell.com/cell-stem-cell…. We're hiring postdocs (NIH-funded) if you like to do more of this type of work! burridgelab.com Northwestern Feinberg School of Medicine

Out now! A single-cell atlas of gene expression and chromatin accessibility of the human developing cortex during mid-gestation identifies prioritized mutations for Autism Spectrum Disorder #neuroscience #developmentalbiology @PascaStanford Stanford University bit.ly/3Es33t6

Published today in Nature Methods together with colleagues from Calico: Enformer - a transformer model that has led to greatly increased accuracy in predicting gene expression from DNA sequence. Blog: dpmd.ai/enformer Paper: dpmd.ai/naturemethods_… 1/

Today we report in Cell our new PE4max and PE5max prime editing systems that we first presented at @CSHLmeetings in August. 1/12 drive.google.com/file/d/1IGiVl7…

Excited to share our latest work using phenotypic screening to identify novel therapeutic targets for DCM @EHJ_ed, led by the talented Isaac Perea academic.oup.com/eurheartj/adva… Stanford CVI Michael Snyder, PhD Salk Institute @StanfordCTSurg Stanford Medicine

Happy to share our paper out in Circulation, in which we developed a novel and robust protocol to generate cardiac pericytes, the most enigmatic cell type in the heart, from hiPSCs. we hope it will help better understand the role of cardiac pericytes in microvascular dysfunction.

Check out our latest work led by Surag Nair & Mo Ameen using neural nets to dissect the interplay of TF stoichiometry, motif affinity & syntax in fibroblast reprogramming to iPSCs. Several fascinating insights from the models. biorxiv.org/content/10.110… Tweetorial coming soon 1/

Excited to share work with co-first author Mo Ameen. Gene regulation is a delicate balance b/w cis-regulatory sequence & TF conc, but these components are often studied in isolation. Reprogramming is a fantastic system to study their interplay 1/16 biorxiv.org/content/10.110…