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Attention deficit/hyperactivity disorder is associated with human CRY1 variants: buff.ly/3d2DfVO Bilkent Üniversitesi #genetics

Genetic Structure of Turkish Population Influenced by Historic Events, Recent Migrations ow.ly/eZhq102U9R3

A large-scale database of genetic variation in Turkey reveals strong inbreeding, deleterious alleles, and a high proportion of rare variants unique to the population. In PNAS: ow.ly/Dn9v50FX3Pk

Check out the new study preprint of Meltem Ece Kars, generating a knowledgebase of currently known categorized COVID-19 severity variants, and performing genomewide machine learning predictions of novel pathogenic COVID-19 variants. medrxiv.org/content/10.110… itanlab.shinyapps.io/COVID19webpage/

It was a pleasure to present our COVID-19 knowledgebase at #biodata22 today! Yuval Itan⁩

Great talk Meltem Ece Kars at the NYC Inborn Errors of Immunity Symposium today. Excellent speakers and discussions. Thanks BogunovicLab and Emily Mace for organizing.

Our new study is now online, a great effort of the IBD Genetics Consortium teams and collaborators. Integrating gene associations, PheWAS, pathway analyses, PRS and transcriptomics for discovering IBD variants and genes in Ashkenazi Jewish patients. yiming wu Judy Cho nature.com/articles/s4146…

Congrats David Stein for the new publication: genomemedicine.biomedcentral.com/articles/10.11… A genome-wide machine learning classifier differentiating gain-of-function from loss-of-function pathogenic human variants. Webserver: itanlab.shinyapps.io/goflof/ A great collaboration with Avner Schlessinger.

Our new publication of the shared genetics between IBD and Parkinson's disease (PD) within a cohort of patients affected by both conditions is online: genomemedicine.biomedcentral.com/articles/10.11… Congrats Meltem Ece Kars who masterfully led this work, and Dr. Inga Peter for the great collaboration.

Excited to share our latest paper where we investigated the shared genetic factors of inflammatory bowel disease and Parkinson’s disease. Many thanks to ⁦Yuval Itan⁩ Dr. Inga Peter Dr. Yiming Wu and all our collaborators. mountsinai.org/about/newsroom…

Now available: updated mutation significance cutoff (MSC) based on CADD v1.7, with gene-specific cutoffs minimizing false negatives in variant filtration: itanlab.org/wp-content/upl… Thanks Meltem Ece Kars and David Stein for testing. Casanova Lab Ref: nature.com/articles/nmeth…

Our new publication on the digenic architecture (two causative genes in a single patient) of congenital heart disease is now online: sciencedirect.com/science/articl… Congrats to Meltem Ece Kars who led this work, and thanks to Bruce Gelb & the PCGC consortium for the collaboration.

A postdoc position is open in my lab to develop AI/ML models for predicting functional effects of genetic variants and to lead large-scale PheWAS in major biobanks. Strong programming skills, a solid publication record, and a background in human genetics are required.