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🧫 Investigators found that Naf1 had a higher expression in CD14+ #monocytes than in monocyte-derived dendritic cells. Their findings may facilitate the understanding of the host restriction of HIV-1 #infection in myeloid cells. 🔬 bit.ly/4hVHYtL

Researchers designed a chikungunya virus (CHIKV) mRNA vaccine that could be a candidate for clinical use against CHIKV. 💉 📖 Find out more in Signal Transduction and Targeted Therapy(STTT): go.nature.com/4l2uZJD

Researchers from the Fourth Military Medical University reveal the underlying molecular mechanisms for the deficiency of MAIT cells during Hantaan virus infection. 📖 Read the full article: go.nature.com/4cf5n87

Big things come in small packages! 📦 Researchers describe the identification of JNJ-9676, a small-molecule inhibitor targeting the #coronavirus M protein. 🖇️ More in nature : go.nature.com/4481sIb

Drs. Volker Lohmann, Eui-Cheol Shin, and team describe the most current knowledge regarding the innate immune response to #hepatitis A virus (HAV) and the HAV-mediated counteractions against innate immune responses. 🔗 go.nature.com/4lc0W2d

Researchers alongside Dr. Filipa Rijo-Ferreira show that approximately half of the mosquito salivary gland transcriptome, particularly genes essential for efficient bloodmeals such as anti-blood clotting factors, exhibits circadian expression. 🦟 Nature Microbiology |

😷 This study highlights the promising anti-Influenza A virus properties of cilnidipine both in vitro and in vivo, suggesting its potential as a clinical agent for emergencies against #influenza outbreaks. BMC Medicine | bit.ly/4ip5Y93

🔗 This study suggests that the expression of ACE2 may partly explain the link of #Alzheimer's disease with #COVID19 infection, hospitalization, and mortality. 👉 molecularpsychiatry | go.nature.com/4ltOFGC

💉 This study provides a powerful approach to enhance the universality and efficacy of neoantigen vaccines, meeting the urgent need for universal neoantigen #vaccines in the clinic to facilitate the further development of tumor immunotherapy. EMBO Mol. Medicine |

💊 Dr. Lucky Sarkar, PhD's team at Cleveland Clinic established the importance of CARD ISGylation for MDA5-mediated RNA virus restriction, promoting potential for immunomodulatory drug design for antiviral or anti-inflammatory applications. PNASNews | bit.ly/3G1ok2i

💉 Check out this study evaluating the association of prophylactic #antiviral therapy with all-cause and cause-specific mortality in cancer patients. 👉 JNCI | bit.ly/42q49Cy

💉 Dr. Thembi Mdluli and team at WRAIR conduct a systems immunology analysis of antibody-mediated and cellular immune responses induced after immunizations with either the Janssen #Ebola virus vaccine or the vaccinia Ankara used first. Science Translational Medicine | bit.ly/4irdvUQ

🫁 Scientists with Drs. Douglas Lauffenburger, Sassetti Lab, and Megan Proulx at UMass Chan Medical School identified strains that control Mycobacterium #tuberculosis comparably to a standard IFNγ-dependent mouse model but with lower lung IFNγ levels. 🔗 Journal of Experimental Medicine | bit.ly/3Go5rXe

🤖 Dr. Azin Rashidy Ahmady and scientists at McMaster University discuss the potential advantages of multi-drive propulsion, bioinspired, and AI-trained medical micro- and nano-bots, with a special focus on challenges and opportunities for commercialization. 👉 bit.ly/42f6jWY

😷💉 This research suggests that A/H1H3 virus-like particle may provide an universal influenza #vaccine capable of providing cross-protection against influenza B virus #infection. 🔓 Emerging Microbes & Infections | bit.ly/4jy2QbA

🔬 Dr. Joaquín Miguel Pellegrini's team at Inserm unravel essential shared multifaceted roles of SLAMF7 and SLAMF8 in finely tuning human plasmacytoid dendritic cells' responses to intracellular bacterial infections. Journal of Clinical Investigation 🔗 bit.ly/44siukr

😷 Researchers at NUS found that ACE2 and TMPRSS2 gene expression was temporarily reduced during the acute phase of #SARSCoV2 infection presumably due to viral disruption of transcription. 📖 Scientific Reports | go.nature.com/3RXOMwe

💉 Investigators at Duke University report on a mode of #hypoallergenic immunogen design that enables immunization against IgE-reactive peptide B cell epitopes by optimizing the distance between epitopes. ACS Nano | bit.ly/4iqeBjD

👏Congratulations to the team on this huge accomplishment! Check it out!

💉 Researchers' immunoinformatics method was used to design a multi-epitope vaccine against Borrelia burgdorferi infection. 🔗 bit.ly/4cIBE7P