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7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (Ajay Labade, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/

Thrilled to report Patho-DBiT, just published in Cell 😊. It allows us to directly “see” all kinds of RNA species on the same clinical FFPE tissue slide, including mRNA, miRNA, snRNA, snoRNA, tRNA, etc, and splicing isoforms, genetic alterations (SNV, CNV, etc). Really a fun,

We now have a way to use spatial imagers to overcome single cell struggles, with stamp biorxiv.org/content/10.110… And a way to use sequencing to overcome spatial imager struggles, with slide tags nature.com/articles/s4158…

Phew…finally! snPATHO-seq, a versatile FFPE single-nucleus RNA sequencing method to unlock pathology archives | Communications Biology Tony Wang, Kate Harvey Michael Roach…you rock guys! Thanks a million to all our collabs and their amazing teams! @dralexswarbrick Joakim Lundberg

snPATHO-seq, a versatile FFPE single-nucleus RNA sequencing method to unlock pathology archives👏 nature.com/articles/s4200…

Thrilled to share two bioRxiv papers from my lab and Lingyan Shi, reporting on the SAME tissue section multi-modality spatial omics! 🤩🥳🙂

If you're around, ping me at the Other Place at bsky.app/profile/ioavla… 🦋

Introducing the Global Alliance for Spatial Technologies (GESTALT) nature.com/articles/s4158… - a groundbreaking global, open, and collaborative scientific effort for spatial biology led by Luciano Martelotto 🛠🧬💻🇦🇺 Dr. Jasmine Plummer 👩🏻‍🔬🧬🇨🇦🇺🇸 Ioannis Vlachos // @ioavlachos.bsky.social !

ChatGPT prefers humans to be polite! A lot of discussion about #thankyou and #please when interacting with LLMs such as ChatGPT & Anthropic. Asked ChatGPT 4.0 and it flipped the narrative on where to focus: the burden is on the developers not users

Thank you Melinda Bachini and Cholangiocarcinoma Foundation for supporting my ASCO YIA application and Conquer Cancer, the ASCO Foundation for funding our study to advance the understanding of cholangiocarcinoma tumor microenvironment. Incredibly grateful for the mentorship from the BI team ML peters, Ioannis Vlachos // @ioavlachos.bsky.social and

Community is key when establishing newer technologies. From the scTrends Consortium’s ‘living review’ to GESTALT, a WhatsApp-based ‘virtual town square’, hear from the experts bringing #singlecell & #spatial scientists together. Download the report now: hubs.la/Q03rPy4j0

Can you do multi-modal multi-million cell single cell studies 𝐰𝐢𝐭𝐡𝐨𝐮𝐭 𝐬𝐩𝐞𝐧𝐝𝐢𝐧𝐠 𝐦𝐢𝐥𝐥𝐢𝐨𝐧𝐬 $$??? 🔥STAMP is fire!!🔥 Multi-million cell atlases are now accessible to all What a milestone! From Luciano Martelotto 🛠🧬💻🇦🇺 Holger Heyn Dr. Jasmine Plummer 👩🏻‍🔬🧬🇨🇦🇺🇸 cell.com/cell/abstract/…