Hello world, ONE is here... I am happy to share with you a new technology —termed #ONE_Microscopy, that allows a resolution approaching ~8 Å using conventional light microscopy. SauerLab Ed Boyden Radu Aricescu Full story: biorxiv.org/cgi/content/sh…

In beautiful Mechelen for the Alzheimer young researcher symposium with Ira Espuny-Camacho giving the keynote talk 🤩

Do you want to apply for a Marie Curie fellowship, to do a postdoc in a cool lab in Barcelona. Join us, I’m recruiting a Marie Curie candidate! We have quite cool to work with brain organoids and the neurodev enhancerome in the lab waiting for you! Look how cool we are

Alzheimer’s drug donanemab: what promising trial means for treatments nature.com/articles/d4158…

Most advanced synthetic human embryos yet spark controversy nature.com/articles/d4158…

Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life | Science Translational Medicine science.org/doi/10.1126/sc…

Gut microbiome composition may be an indicator of preclinical Alzheimer’s disease | Science Translational Medicine science.org/doi/10.1126/sc…

Young glial progenitor cells competitively replace aged and diseased human glia in the adult chimeric mouse brain | Nature Biotechnology nature.com/articles/s4158…

Older mouse brains rejuvenated by protein found in young blood nature.com/articles/d4158…

Platelet factors attenuate inflammation and rescue cognition in ageing | Nature nature.com/articles/s4158…

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease | Science science.org/doi/10.1126/sc…

There are now hundreds of genes associated with autism & neurodevelopmental disorders but what key processes in brain development they each disrupt remains unknown. In an article in nature today, we start tackling this question by combining forebrain #assembloids with CRISPR

Here comes the tweetorial of our recent work in the preprint biorxiv.org/content/10.110…, where we present first draft of human neural organoid cell atlas HNOCA, by integrating 1.8 million cells from scRNA-seq data sets representing 26 different neural #Organoids protocols

Is CRISPR safe? Genome editing gets its first FDA scrutiny nature.com/articles/d4158…

AI that reads brain scans shows promise for finding Alzheimer’s genes go.nature.com/47z7tMR

The first pre-print of my team is out. In collaboration with Laurent Nguyen, Jean-Claude Twizere and Emmanuel di Valentin: SARS-CoV2 infection triggers reactive astrocyte states and inflammatory conditions in long-term Human Cortical Organoids | bioRxiv biorxiv.org/content/10.110…

Glad to have participated in this great work from my former lab in Italy on stem cell models to study HD: Huntington’s disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids | Nature Communications nature.com/articles/s4146…

‘Big leap’ for Parkinson’s treatment: symptoms improve in stem-cell trials nature.com/articles/d4158…

Vota a Decidim Barcelona per aconseguir unes platges veritablement accessibles. Data límit dissabte 17 de maig. Màxima difusió! decidim.barcelona/processes/pres…

Finally accepted in Stem Cells! Our work shows the effect of SARS-CoV2 infection in the brain using human brain organoids. SARS-CoV2 infection triggers inflammatory conditions and astrogliosis-related gene expression in long-term human cortical organoids academic.oup.com/stmcls/article…