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We have liftoff! 🚀 Excited to share our new work revealing an essential role of the transcription factor SRF in John Haddad, out today PNASNews. Led by the amazing tal.iram and Miguel Garcia in collaboration with Fabian Kern 🦋 @fabianmkern, Tony Wyss-Coray, and their labs.

What Alzheimer noted as fat saccules in glia may have been lipid droplets. They can be induced by Abeta in microglia leading them to release factors that damage neurons. ApoE4 makes things worse rdcu.be/dA6Kh. Congrats Michael Haney Robert Palovics and fantastic team

Congrats to the team again, and thanks to Dr. Andrew Olson for imaging this beautiful #oligodendrocyte #cytoskeleton featured on the cover

Brain signaling depends on myelin insulation — which declines with age and in disorders like MS. New research led by @tal_iram and Miguel Garcia in ZucheroLab finds a driver of myelin formation that could lead to new therapies to maintain brain health. neuroscience.stanford.edu/news/unlocking…

Interested in research on aging and neurodegeneration? Tony Wyss-Coray lab has 2 LSRP positions open! If you're interested and meet the requirements in the posting, please apply and reach out directly to me or Ian Guldner! See the application link here. careersearch.stanford.edu/jobs/life-scie…

Three-photon microscopy for long-term in vivo three-photon imaging of the entire cortical column and subcortical white matter in adult mice reveals region-specific differences in healthy and regenerative #oligodendrocyte formation Ethan Hughes et al. nature.com/articles/s4159…

Once thought to be a static structure, mature myelin made by oligodendrocytes has been full of surprises. Check out our new review on the topic!

Immunity Our paper on using the novel Clec7a-CreER mouse to label, track and manipulate PAM/DAM microglial states is finally out in Immunity Congrats to the first author Kia Barclay Kia Barclay Many thanks to the collaborators from The Colonna Lab Kipnis Lab Yu Lab @ Tsinghua Saligrama lab_WUSTL

Please retweet! TWO open position for PhD candidates at my lab and Thomas Boulin's lab The Boulin Lab, within the framework of the European Training Network: Molecular plasticity of neurons during C. elegans lifespan. for more info- excitingworms.eu/nervspan/index…

Out in nature today - the research that has been such a huge part of my life over these past few years. Myelin plasticity is a critical component of neural circuit modifications opioids evoke to drive reward learning.

Excited to share our recent work in @cellcellpress: Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain: Cell cell.com/cell/fulltext/… beth stevens 1/n

Oligodendrocytes produce amyloid-β in AD mice and reveal a threshold for plaque deposition. Great study by Andrew Sasmita, Constanze Depp et al. nature.com/articles/s4159…

Out now! “Schwann cell-secreted PGE2 promotes sensory neuron excitability during development.” Published online today Cell. authors.elsevier.com/a/1jbBiL7PXqRXI

What an amazing way to start the lab! We cant wait to uncover more mechanisms of oligodendrocyte and myelin plasticity and learn how it impacts cognitive aging. More details in our website - weizmann.ac.il/molneuro/iram/ DM or email me if you are interested to join the team! #ERCStG

Preprint is finally out! Mapping whole brain oligo-myelin patterns across individual mice, sex, strain, aging, and injury (biorxiv.org/content/10.110…) Check out some cool videos as well! vimeo.com/1003497448?ts=… And play around with the beautiful raw data! tinyurl.com/5n87z2xs

Great work by @sophiesiems @SGargareta Vinicius Gastaldi Hauke Werner etc. investigating CNS myelin proteomic heterogeneity across different ages, sex, and major regions in vivo 🐚👏 onlinelibrary.wiley.com/doi/10.1002/gl…

A year in ongoing trauma is difficult to explain, but it’s difficult for me to concentrate on anything else. Sorry for the long long post. This year, I’ve dealt with traumas on multiple levels.

It has been one year since the unthinkably evil events of Oct. 7 2023. My heart, still in pieces, is with those mourning their loved ones and those still enduring unimaginable horrors at the hands of the terrorists who kidnapped them. #LetThemGoNow

🚨📢 Excited to announce our new paper in Science Advances! We’ve uncovered how Shank3 mutations affect myelination in an autism mouse model and human iPSC-derived OPCs. 🧠💡 Check it out! science.org/doi/10.1126/sc…

סטודנטים/יות ופוסט-דוקים/יות, ההרשמה לכנס בנוירוביולוגיה תאית ומולקולרית תיסגר בעוד שלושה ימים (3 בנובמבר)! יש עדיין סלוטים להרצאות ופוסטרים, אז מהרו להירשם (זה בחינם) ולהגיש תקציר (erez.weizmann.ac.il/apx/r/ws1/101/…). מחכים לראותכם במכון ויצמן ב 17 בנובמבר!