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nature.com/articles/d4158…

forbes.com/sites/bryanrob…

16 resources for re-analyzing public expression data. 👇 🧵

A great programmer, guy to be missed hackread.com/vim-text-edito…

AlphaMissense, a tool by DeepMind, can help researchers learn more about the effects that missense mutations have on disease, and could help identify previously unknown disease-causing genes, according to a new Science study. Learn more: scim.ag/49l

Our paper is out, Bravo and thanks to all the contributors!!👏👏 Take home: after DSB induction, gH2AX domains self-segregate to form a new chromatin compartment, in which some DDR genes also physically relocate to potentiate their expression. rdcu.be/doT6W

a really cool command line data viewer, it’s really cool and useful for us dealing with command line/data analysis all day: jsvine.github.io/intro-to-visid…

"a new generation of AlphaFold that can handle arbitrary interactions of proteins, nucleic acids, arbitrary small molecule ligands, and modified or non-canonical residues." - storage.googleapis.com/deepmind-media…

1/N Finally out!! -- 30Gy for HPV+OPC in Journal of Clinical Oncology – work by the Memorial Sloan Kettering Cancer Center Head and Neck team, led by Nancy Lee, Eric Sherman, and myself on using hypoxia imaging response to cut treatment 60% (70->30Gy)! #radonc #hncsm ascopubs.org/doi/10.1200/JC…

techradar.com/pro/exclusive-…

Wow, @nature has retracted the 2020 Poore et al. cancer microbiome paper that we showed (journals.asm.org/doi/10.1128/mb…) was deeply flawed. The retraction date is tomorrow so I can't yet read the official notice, but I'll update when I can Retraction Watch Professor Booty PhD

1/9 Excited to share our latest publication! Check out our paper: “Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors” #Cancer #BRCA #CopyNumberAlterations #GenomeMedicine doi.org/10.1186/s13073…

New paper out! Led by Yingjie Zhu and ipstone. We tried to figure out how BRCA-related cancers compensate from a proliferative deficit induced by HRD. See great tweetorial below on what we found 👇👇

Featured today by MSK Library: Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors dx.doi.org/10.1186/s13073…

a great insight from: oreilly.com/radar/the-end-… "User expectations are also going to rise. Businesses that simply use the greater productivity to cut costs will lose out to companies that invest in harnessing the new capabilities to build better services."

🧵 Paradigm-buster just out: ATM-deficient tumors stay cold ❄️—unlike other DNA-repair defects—so PD-1 blockade alone (or with ATRi) falls flat. We mapped the biology in mice + patients. Paper in @JITCancer now (link below) -- #ImmunoOncology #DNArepair OncoAlert (1/9)

storage.googleapis.com/deepmind-media…

1/ 🧬Our paper is out JCO Precision Oncology! We tested AlphaMissense(an AI tool for predicting the pathogenicity of missense mutations), across DNA damage repair genes in cancer. Key finding: accuracy varies dramatically by gene - crucial for clinical use! ➡️ ascopubs.org/doi/full/10.12…