🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Our latest work, led by Benjamin Jackson and Angela Montero Memorial Sloan Kettering Cancer Center demonstrates how intracellular metabolic gradients induce dependence on exogenous pyruvate in embryonic stem cells

Several groups have reported that prolonged high-altitude exposure lowers blood glucose. But the mechanisms have been unclear. Yolanda performed elegant experiments showing that expansion of red blood cells in hypoxia is largely responsible for this improved glucose tolerance!

Check out our latest preprint, led by Siyu Chen, that brings together an amazing team of scientists from several labs to tackle a fundamental problem in biology: how do cells regulate expression of their tRNAs? biorxiv.org/content/10.110…

The Sable Award lecture at METPHYS2025 was really remarkable! Tremendous congratulations to this years exceptional member of our community Kivanc Birsoy

We are excited to announce our 2025 UofU Diabetes Postdoctoral Rising Stars in Metabolism Symposium! This is truly a unique opportunity to network, present your research, and enjoy the breathtaking views that Salt Lake City has to offer. Deadline is May 15th, 2025. Please share!

Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new Arc Institute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement

Come work with us at Arc Institute

We're hiring a CSO to lead our institute initiatives!

Congrats Javier Garcia-Bermudez lab on this fantastic discovery! So well deserved!!! This needs to be considered for future ferroptosis work in vivo.

We are deeply saddened by the passing of Dr. Atul Butte, a visionary scientist, educator and leader whose work reshaped biomedical research and health care. We extend our heartfelt condolences to Dr. Butte’s family, colleagues, trainees and collaborators. ucsfh.org/4n25xVH

Very proud of the hard work and resilience by Eddie Rashan, Abby Bartlett and many others on this work!

Today Arc Institute releases State, our first perturbation prediction AI model and an important step towards our goal of a virtual cell State is designed to learn how to shift cells between states (e.g. “diseased” to “healthy”) using drugs, cytokines, or genetic perturbations

Preprint drop from our team at Arc Institute! Introducing STATE: a model that learns and predicts transcriptomic responses to chemical or genetic perturbations. This is the first model to beat simple linear baselines and our first step toward building a virtual cell model.

Register today for the Virtual Cell Challenge and use AI to solve one of biology’s most complex problems. Announced in Cell, the competition is hosted by Arc Institute and sponsored by NVIDIA, 10x Genomics, and Ultima Genomics.

Announcing the inaugural Virtual Cell Challenge! Hosted by Arc Institute, and sponsored by Nvidia, 10x, and Ultima, help solve one of biology’s biggest challenges with AI by building cell state models that accurately predict responses to perturbation. virtualcellchallenge.org

Delighted to announce Arc Institute's Virtual Cell Challenge - a recurring, open, community-driven challenge to benchmark cellular foundation models See our announcement in Cell below, with prizes up to $100,000, sponsored by @Nvidia 10x Genomics Ultima Genomics!

Online Now: An NADH-controlled gatekeeper of ATP synthase dlvr.it/TLbSJS