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🐖 What happens when pigs catch PRRSV vs. swine flu? Bertho (INRAE/ONIRIS) found PRRSV triggers cytokines (IL-5, CXCL13, BAFF) but no neutralizing antibodies—unlike influenza. ➡️ Possible immune impairment during co-infection. 📢 BioRxiv Preprint #ISIDORe #PRRSV #OneHealth

🧠 How do bunyaviruses evade host defenses? Gerlach’s team (Polish Academy of Sciences), with #ISIDORe & EMBL, revealed how viral proteins mimic SG partners to hijack G3BP1—disrupting stress granules. 🔬 Crystal structures + cell imaging 📢 To be shared at EMBO/NSV 2025

🧫 KlebsiGene: a DNA vaccine against Klebsiella. López Siles (Univ. of Girona) advanced regulatory strategy & safety validation with ISIDORe, EATRIS & FIMM. ✔️ TPP defined ✔️ No DNA integration ✔️ Transcriptomics ongoing #ISIDORe #DNAVaccine #AMR #Klebsiella #VaccineDevelopment

🧪 What did we learn from #COVID-19 immunity in healthcare workers? A study in Spain with #ISIDORe support found low memory T cell signals but broader CD4/CD8 shifts. Despite limits, it informs post-vaccine immunity & feeds into long COVID & KAP studies. #Tcells #PublicHealth

🧬 Blocking poxvirus fusion = blocking infection. With #ISIDORe, Guardado-Calvo’s team solved a fusion complex subunit bound to inhibitor & generated nanobodies targeting 4 subunits. Next: test neutralization & solve top structures. #Poxvirus #Antivirals #CryoEM #Nanobodies

🦋 Silkworms for vaccines? French biotech NEVEZYNE is developing a low-cost, scalable platform—starting with Ebola GP antigen. With #ISIDORe & EATRIS support, they refined their regulatory strategy & TPP to prep for clinical steps. #VaccineInnovation #Biomanufacturing #Ebola

🦠 New malaria drug target? Kobakhidze (Max Perutz Labs) used ISIDORe & EMBL’s HTX Lab to solve the structure of PfSET7—revealing a parasite-specific pocket absent in humans. 🎯 A key step toward selective antimalarials. #ISIDORe #Malaria #PfSET7 #DrugDiscovery #StructuralBiology

🧬 How do viral & human proteins move? With #ISIDORe, Spyroulias & Fourkiotis (U. Patras) used NMR to compare SARS-CoV-2 & PARP9 macro domains. 📍 Key finding: PARP9 MD2 shows dynamic flexibility—key to ligand binding & drug design. #NMR #MacroDomains #SARSCoV2 #DrugDiscovery

🧫 Can a DNA vaccine stop Klebsiella? At Univ. of Girona, López Siles’ team is developing KlebsiGene to prevent drug-resistant infections. With #ISIDORe/EATRIS, they confirmed no DNA integration & began transcriptome analysis. #Klebsiella #DNAVaccine #AMR #VaccineDevelopment

🧬 What do symptoms reveal about SARS-CoV-2 mutations? In 428 healthcare workers, Milagro Beamonte’s team used Whole Genome Sequencing (WGS) to link S gene mutations (esp. in JN.1) with malaise. WGS outperformed PCR for mutation detail—vital for real-time surveillance. #ISIDORe

🧱 Can we break the TB barrier? With #ISIDORe support, Kobakhidze (Max Perutz Labs) & EMBL Grenoble identified 2 fragments binding MmaA1, a key enzyme in Mtb’s lipid wall. One fragment shifts a critical loop—hinting at drug potential. #Tuberculosis #DrugDiscovery

🫁 Can we prevent lung damage after TB? Dr. Rath & OSPF (India) are launching a global Phase III trial testing metformin + NAC for post-TB recovery—thanks to #ISIDORe & #EATRIS support ✔️ TPP, trial design & WHO feedback secured. tinyurl.com/5hbff3h2 isidore-project.eu/user-conferenc…

🦠 What does TBEV entry into neurons look like? With #ISIDORe & CEITEC (Instruct CZ), Bisikalo (Helsinki) used cryo-ET to image TBEV on GLP2R-liposomes—confirming cryo-ET compatibility. Next: higher-res data to reveal the virus–host interface. #TBEV #CryoEM #Neurovirology

🧬 How do SARS-CoV-2 mutations boost fitness? With #ISIDORe, Blackledge (IBS Grenoble) used high-field NMR to show that N protein mutations (e.g. Q229K, R203M) reshape structure & RNA binding. Disorder = function. #SARSCoV2 #Nucleocapsid #NMR #ViralFitness #ProteinDisorder

🌍 At Institut Pasteur, we joined field training at MORU Bangkok with Prof. Phaik Yeong Cheah’s team to explore meaningful community engagement for #CCHF & #TBE. Practical insights to boost future preparedness & train tomorrow’s researchers! 👥🧪 #ISIDORe #PublicHealth

Some hundred miles away we are discussing similar crucial issues in the context of the project ISIDORe ERINHA director highlighting the importance of funding of research infrastructure for preparedness to health challenges both in Europe and the world Instruct-ERIC

Great to read about Instruct-ERIC researchers! ISIDORe Meeting give the opportunity to hear from users of other infrastructures Instruct is always looking for synergies and services we can provide together Just seen 2 posters of users of both Instruct-ERIC and EU-OPENSCREEN ERIC

Peter Doran University College Dublin presenting the Joint Research Activities #JRA session ISIDORe user meeting today in Paris Instruct-ERIC shared their knowledge and expertise in three of these JRAs some of them will be presented today We join Peter in thanking ERINHA coordination

Attending 2nd ISIDORe user conference in Paris and glad to see EATRIS user’s community research results for Pandemic Preparedness

Some partners of our project took part at the ISIDORe User Conference in Paris 🇫🇷 to discuss about pandemic preparedness and response👇 We participated in roundtable discussions to enhance global preparedness for future health emergencies.