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I did a simple experiment to check how much gene expression differs between mouse and human cells? Answer-quite a lot, how to tackle it? Check the preservation of signals for your cell-type of interest. This one I call it, “An eye of a Tumor”, Paper out soon in Cancer Discovery.

Woman in cancer remission for record 19 years after CAR-T immune treatment nature.com/articles/d4158…

Spread positivity…being PhD students is not that bad, if you follow these principles.

St. Jude scientists leveraged findings about how cancer cells reduce the effectiveness of immunotherapy to suggest a combination treatment to reduce leukemia relapse. Read more: ow.ly/VhTj50V69eE

Now online in Cancer Discovery: GPR65 Inactivation in Tumor Cells Drives Antigen-Independent CAR-T Cell Resistance via Macrophage Remodeling - by Jayadev Mavuluri, Yogesh Dhungana (Pronounced: Dhung-gä-nä),Jiyang Yu, Terrence Geiger, and colleagues doi.org/10.1158/2159-8… St. Jude Research

Now online! Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions dlvr.it/TJfQFb

Beautiful work by my wonderful colleague Jiyuan Yang, PhD! A step towards adding spatial awareness in our analysis! Congratulations to my mentor Jiyang Yu, The Yu Lab is on fire 🔥 this year!

This month we are remembering Rockefeller's Bruce McEwen, best known for his studies on how stress hormones reshape neural circuits and brain structures. Learn more about his life and legacy below. #NationalStressAwarenessMonth youtube.com/watch?v=dK7aM6…

I don’t know why I was procrastinating on reading “Zero to one”, it’s an eye opening book. First thing I thought about was single-cell gene expression matrix 😂.

A milestone paper from The Yu Lab. What a ride, saw this tool from its infancy to a full fledged package. Proud to be able to contribute to the team’s efforts. nature.com/articles/s4146… Congratulations to the team who lead the effort and to my mentor Jiyang Yu

From the May issue: GPR65 Inactivation in Tumor Cells Drives Antigen-Independent CAR-T Cell Resistance via Macrophage Remodeling brnw.ch/21wSZir By Jayadev Mavuluri, Yogesh Dhungana (Pronounced: Dhung-gä-nä), Jiyang Yu, Terrence Geiger, and colleagues. St. Jude Research

Going for the “killing the snake” part of my dissertation in 2 months, is it still an active part of the PhD tradition or not anymore? What is #phddefence recommendation on how should I approach it? St. Jude Graduate School of Biomedical Sciences #systemsbiology #PhDone