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Out today in Nature Genetics, our group’s single-cell MPRA technology for testing activities of gene regulatory elements in whole tissues. Congrats to Siqi Zhao and the rest of the crew for their great work! nature.com/articles/s4158…

Very excited to share a new preprint from the durocherlab! We used AlphaFold2 to exhaustively map the 53BP1-RIF1-shieldin-CST pathway and found a novel RIF1-SHLD3 binding interface essential for pathway function. 🧵below 1/6 biorxiv.org/content/10.110…

RESEARCH | Led by Zhaohui Feng (Rutgers University): The authors identify a non-metabolic mechanism through which LDHA promotes cancer progression. LDHA, independently of its enzymatic activity, directly interacts with & activates Rac1. nature.com/articles/s4225…

Chem-map profiles drug binding to chromatin in cells go.nature.com/3ZV69Rj

Estimation of activity changes for >500 kinases & transcription factors in >1,000 cancer samples & cell lines identifies drivers of signalling dysregulation & patient survival ➡️ bit.ly/3Jb9l5b Pedro Beltrao IMSB_ETH Saez-Rodriguez Group Uni Heidelberg Evangelia Petsalaki EMBL-EBI

I’m excited to share a new #cancer #metabolism preprint where we explore nutrient transport in cells and tumors in CRISPRi/a screens. biorxiv.org/content/10.110… Our question: How do small molecules like nutrients and drugs get in and out of cells? 🧵(1/12)

Please RT. We are recruiting a postdoc! We look for someone motivated and sharing our interest in #histone_variants and #leukemia. More info👇 🌐 buschbecklab.org

Awesome story characterizing how fumarare triggers immune response! Congrats to all, super proud! 🙌🏼

Our work on the discovery of a biochemical mechanism through which lactate regulates protein function, cell cycle, and proliferation, is out today in @nature. Congrats to lead authors Weihai, Yun, Luiz Bozi & Patrick! A 🧵 @HarvardCellBio Dana-Farber nature.com/articles/s4158…

whoa, what a day... a milestone for mitochondrial biology in cancer from the Shackelford lab! nature.com/articles/s4158…

Delighted to introduce PMF-seq: a new way to link genetic perturbations to detailed bioenergetic phenotypes. We use the method to dissect genetics of mitochondrial ETC branching and acute tBID action. Led by T.L.To ⁦Broad Institute⁩. nature.com/articles/s4225…

Nature research paper: Decoding chromatin states by proteomic profiling of nucleosome readers go.nature.com/3P7kNRC

Nature research paper: Universal recording of immune cell interactions in vivo go.nature.com/3T9n3ca

Excited to share my postdoc work out in Nature Chemical Biology! We explored the preferences and efficiencies of ATP pathways in cells and tissues. By quantifying metabolic flux and proteomics, we found that respiration makes ATP faster per enzyme mass than glycolysis🧵nature.com/articles/s4158…

💫NEW: Martin Wühr, brangwynnelab & co use filtration chromatography & quantitative #proteomics of Xenopus egg extracts and show that at least 18% of cytoplasmic proteins are organized in small ~100-nm #BiomolecularCondensates. 👉rdcu.be/dAFJS nature.com/articles/s4155…

📢 PhD position available in our #research group 📢 We have an exciting project for a motivated #PhD student to study the impact of gender-affirming therapy on #bone! More info 👇: kuleuven.be/personeel/jobs… Please share and RT! KU Leuven ECTS_Science ECTS Academy ASBMR

REVIEW | Liron Bar-Peled & Nora Kory (Harvard T.H. Chan School of Public Health): Metabolic compartmentalization can shape organismal #metabolism, while its dysregulation can lead to pathological states. #TBT nature.com/articles/s4225…

It was a lot of fun diving deep into the world of fumarate-induced succination with FrezzaLab! I hope you enjoy the read!

Thrilled to share our study on anti-tumor immunity during aging with James SeongJun Han, PhD Alison E Ringel @HaigisLab. Here we demonstrate that the loss of tumor-reactive CD8+ T cells is a cardinal feature that accelerates tumor outgrowth in aged mice and promotes resistance to immune

Check out these three Reviews touching on diseases: 📝Fumarate-induced succination in kidney cancer (Iva Guberovic FrezzaLab) 📝Atherosclerosis-induced metabolic reprogramming (Claudio Mauro Mauro Research Group 𝘔𝘪𝘤𝘩𝘦𝘭𝘢𝘯𝘨𝘦𝘭𝘰 𝘊𝘦𝘳𝘵𝘰) 📝JMJD proteins in development and as drug targets